Cohorts | TTG-0 | TTG-1 | TTG-2 | Beta (95% CI) | P value | FDR |
NYU (n=372) | 3.43 (±1.44) (n=83) | 3.28 (±1.45) (n=209) | 2.60 (±1.70) (n=57) | −0.39 (−0.64 to −0.13) | 0.0030 | 0.0046 |
GOGO (n=339) | 3.67 (±1.31) (n=111) | 3.08 (±1.51) (n=138) | 3.35 (±1.38) (n=90) | −0.18 (−0.38 to 0.02) | 0.0049 | 0.0950 |
OAI (n=355) | 3.40 (±1.46) (n=86) | 3.20 (±1.63) (n=200) | 3.09 (±1.81) (n=61) | −0.16 (−0.42 to 0.10) | 0.4787 | 0.2364 |
All (n=1066) | 3.52 (±1.40) (n=280) | 3.20 (±1.53) (n=547) | 3.07 (±1.63) (n=208) | −0.23 (−0.37 to −0.10) | 0.0023 | 0.0021 |
All meta-analysis (n=1066) | – | – | – | −0.23 (−0.37 to −0.10) | 0.0008 | 0.0021 |
mJSW data are presented in millimetres as mean (±SD) unless otherwise indicated; number of subjects in each group is represented in square brackets below each value. Haplotypes TTG-0 or TTG-1 or TTG-2, respectively, represent carriers of 0 or 1 or 2 copies of IL1RN haplotype produced using 3 IL1RN single nucleotide polymorphisms (rs419598, rs315952 and rs9005). Linear regression model (beta and 95% CI) was performed and p value was adjusted by FDR. The last row indicates the meta-analysis of all three cohorts by including cohort as a covariate.
FDR, false discovery rate; GOGO, Genetics of Generalized Osteoarthritis; NYU, New York University; OAI, osteoarthritis initiative.