Baseline characteristics
| Key characteristics | Categories | Naproxen | Colchicine |
| Age: mean (SD) | – | 58.7 (14.4) | 60.0 (13.4) |
| Male, n (%) | 173 (86.5) | 174 (87.4) | |
| Pain NRS (0–10), mean (SD) | – | 7.1 (2.1) | 6.9 (2.2) |
| Missing data | 7 | 5 | |
| First instance of gout, n (%) | – | 35 (17.9) | 51 (26.2) |
| Missing data | 4 | 4 | |
| Age when diagnosed, mean (SD) | 52.1 (15.2) | 53.4 (14.6) | |
| Missing data | 6 | 7 | |
| Body part affected, n (%) | First MTPJ | 142 (72.4) | 135 (69.2) |
| Other foot joints | 58 (29.6) | 48 (24.6) | |
| Other lower limb | 46 (23.5) | 47 (24.1) | |
| Upper limb | 23 (11.7) | 31 (15.9) | |
| Missing data | 4 | 4 | |
| Number of body parts affected, n (%) | 1 | 139 (70.9) | 145 (74.3) |
| 2 | 34 (17.3) | 27 (13.8) | |
| 3 | 13 (6.6) | 9 (4.6) | |
| 4 | 6 (3.1) | 13 (6.7) | |
| ≥5 | 4 (2.0) | 1 (0.5) | |
| Missing data | 4 | 4 | |
| EQ-5D-5L, mean (SD) | – | 0.665 (0.210) | 0.666 (0.225) |
| Missing data | 8 | 6 |
MTPJ, metatarsophalangeal joint; NRS, Numeric Rating Scale.