Table 5

Performance of various thresholds of the 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease using validation cohort 1

Threshold	Sensitivity (95% CI)	Specificity (95% CI)	AUC (95% CI)	Youden index	Distance to (0,1)	Specificity–sensitivity	Diagnostic OR
14	0.89 (0.86 to 0.92)	0.95 (0.91 to 0.97)	0.92 (0.90 to 0.94)	0.84	0.12	0.06	142.4
15	0.89 (0.85 to 0.91)	0.97 (0.95 to 0.99)	0.93 (0.91 to 0.95)	0.86	0.12	0.09	286.1
16	0.89 (0.85 to 0.91)	0.98 (0.96 to 0.99)	0.93 (0.92 to 0.95)	0.87	0.12	0.10	394.5
17	0.88 (0.85 to 0.91)	0.98 (0.96 to 0.99)	0.93 (0.92 to 0.95)	0.86	0.12	0.10	385.6
18	0.88 (0.84 to 0.90)	0.98 (0.96 to 0.99)	0.93 (0.91 to 0.95)	0.86	0.13	0.11	360.8
19	0.86 (0.83 to 0.89)	0.99 (0.92 to 0.99)	0.93 (0.91 to 0.94)	0.85	0.14	0.12	408.3
20	0.86 (0.82 to 0.89)	0.99 (0.97 to 0.99)	0.92 (0.91 to 0.94)	0.85	0.15	0.14	761.5
21	0.83 (0.79 to 0.86)	0.99 (0.97 to 100.0)	0.91 (0.89 to 0.93)	0.82	0.18	0.17	607.2
22	0.82 (0.78 to 0.85)	0.99 (0.97 to 0.99)	0.91 (0.89 to 0.92)	0.81	0.18	0.18	578.8

AUC, area under the curve.