Table 3

Pathways with significant case–control discrepancy

GO termSet size p-value q-valueName
GO:000588673201.0×10−6 1.3×10−4 Plasma membrane
GO:000681044841.0×10−6 1.3×10−4 Transport
GO:000487210621.1×10−6 1.3×10−4 Receptor activity
GO:00092798671.1×10−6 1.3×10−4 Cell outer membrane
GO:00058293051.3×10−6 1.3×10−4 Cytosol
GO:00302882061.4×10−6 1.3×10−4 Outer membrane-bounded periplasmic space
GO:00425971621.4×10−6 1.3×10−4 Periplasmic space
GO:00719731541.4×10−6 1.3×10−4 Bacterial-type flagellum-dependent cell motility
GO:0042802591.6×10−6 1.3×10−4 Identical protein binding
GO:00302467542.3×10−6 1.7×10−4 Carbohydrate binding
GO:0016485593.1×10−6 2.1×10−4 Protein processing
GO:00167576583.4×10−6 2.2×10−4 Transferase activity, transferring glycosyl groups
GO:00160209596.6×10−6 3.8×10−4 Membrane
GO:0048038931.0×10−5 5.3×10−4 Quinone binding
GO:00150312421.1×10−5 5.3×10−4 Protein transport
GO:00058875261.2×10−5 5.6×10−4 Integral component of plasma membrane
GO:004687267472.0×10−5 8.9×10−4 Metal ion binding
GO:000815223142.5×10−5 0.0011Metabolic process
GO:0006518645.0×10−5 0.0020Peptide metabolic process
KEGG pathwaySet size p-value q-valueDefinition
ko007907404.3×10−5 0.0080Folate biosynthesis
ko001301751.2×10−4 0.011Ubiquinone and other terpenoid-quinone biosynthesis
ko006331084.1×10−4 0.025Nitrotoluene degradation
B215805.5×10−4 0.025Transport and catabolism
ko000618346.7×10−4 0.025Fatty acid biosynthesis
ko049201180.00160.045Adipocytokine signalling pathway
ko04016870.00170.045MAPK signalling pathway-plant
ko005312570.00200.045Glycosaminoglycan degradation

  • GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.