Pathways with significant case–control discrepancy
GO term | Set size | p-value | q-value | Name |
GO:0005886 | 7320 | 1.0×10−6 | 1.3×10−4 | Plasma membrane |
GO:0006810 | 4484 | 1.0×10−6 | 1.3×10−4 | Transport |
GO:0004872 | 1062 | 1.1×10−6 | 1.3×10−4 | Receptor activity |
GO:0009279 | 867 | 1.1×10−6 | 1.3×10−4 | Cell outer membrane |
GO:0005829 | 305 | 1.3×10−6 | 1.3×10−4 | Cytosol |
GO:0030288 | 206 | 1.4×10−6 | 1.3×10−4 | Outer membrane-bounded periplasmic space |
GO:0042597 | 162 | 1.4×10−6 | 1.3×10−4 | Periplasmic space |
GO:0071973 | 154 | 1.4×10−6 | 1.3×10−4 | Bacterial-type flagellum-dependent cell motility |
GO:0042802 | 59 | 1.6×10−6 | 1.3×10−4 | Identical protein binding |
GO:0030246 | 754 | 2.3×10−6 | 1.7×10−4 | Carbohydrate binding |
GO:0016485 | 59 | 3.1×10−6 | 2.1×10−4 | Protein processing |
GO:0016757 | 658 | 3.4×10−6 | 2.2×10−4 | Transferase activity, transferring glycosyl groups |
GO:0016020 | 959 | 6.6×10−6 | 3.8×10−4 | Membrane |
GO:0048038 | 93 | 1.0×10−5 | 5.3×10−4 | Quinone binding |
GO:0015031 | 242 | 1.1×10−5 | 5.3×10−4 | Protein transport |
GO:0005887 | 526 | 1.2×10−5 | 5.6×10−4 | Integral component of plasma membrane |
GO:0046872 | 6747 | 2.0×10−5 | 8.9×10−4 | Metal ion binding |
GO:0008152 | 2314 | 2.5×10−5 | 0.0011 | Metabolic process |
GO:0006518 | 64 | 5.0×10−5 | 0.0020 | Peptide metabolic process |
KEGG pathway | Set size | p-value | q-value | Definition |
ko00790 | 740 | 4.3×10−5 | 0.0080 | Folate biosynthesis |
ko00130 | 175 | 1.2×10−4 | 0.011 | Ubiquinone and other terpenoid-quinone biosynthesis |
ko00633 | 108 | 4.1×10−4 | 0.025 | Nitrotoluene degradation |
B21 | 580 | 5.5×10−4 | 0.025 | Transport and catabolism |
ko00061 | 834 | 6.7×10−4 | 0.025 | Fatty acid biosynthesis |
ko04920 | 118 | 0.0016 | 0.045 | Adipocytokine signalling pathway |
ko04016 | 87 | 0.0017 | 0.045 | MAPK signalling pathway-plant |
ko00531 | 257 | 0.0020 | 0.045 | Glycosaminoglycan degradation |
GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.