Comparison of differences in false-negative and true-positive IgG4-related disease cases from the validation cohorts*
| Validation cohort 1 | Validation cohort 2 | |||||
| False negatives (n=62) | True positives (n=366) | P value | False negatives (n=48) | True positives (n=219) | P value | |
| Male sex | 38 (61) | 244 (67) | 0.4 | 29 (60) | 150 (69) | 0.3 |
| Age at diagnosis, mean ± SD, years | 57.5±14.9 | 60.5±13.4 | 0.1 | 60.4±15.9 | 58.8±14.8 | 0.5 |
| Age at symptom onset, mean ± SD, years | 55.6±15.0 | 58.6±14.0 | 0.1 | 57.9±16.2 | 56.7±15.3 | 0.6 |
| No of organs involved, median (IQR) | 2 (1–3) | 3 (2–4) | 0.002 | 2 (1–3) | 2 (2–4) | 0.01 |
| Biopsy performed | 40 (65) | 332 (91) | <0.001 | 35 (73) | 193 (88) | 0.007 |
| Reason criteria not met | ||||||
| Exclusion criteria present | 20 (32) | – | 9 (19) | – | ||
| Clinical | 7 (11) | – | 4 (8) | – | ||
| Serological | 7 (11) | – | 3 (6) | – | ||
| Radiological | 5 (8) | – | 2 (4) | – | ||
| Pathological | 2 (3) | – | 0 (0) | – | ||
| Inclusion criteria score <20 | 43 (69) | – | 39 (81) | – | ||
| Total points toward inclusion criteria, mean±SD | 22.9±17.1 | 38.9±12.2 | <0.001 | 18.6±11.9 | 37.9±12.7 | <0.001 |
*'Gold standard’ cases and mimickers were used in this analysis. Except where indicated otherwise, values are the number (%).