Mean (SD)* | DE019 (N=207) | ||||||
Disease duration | Prior DMARD treatment | ||||||
≤1 year n=9 | >1–5 years n=62 | >5–10 years n=43 | >10 years n=93 | MTX+0–1 n=75 | MTX+2 n=62 | MTX+>2 n=70 | |
Age, years | 55.2 (18.0) | 51.3 (15.7) | 56.6 (12.3) | 59.1 (11.1) | 58.7 (2.8) | 54.4 (14.7) | 54.7 (12.9) |
Sex, female, n (%) | 5 (55.6) | 48 (77.4) | 33 (76.7) | 72 (77.4) | 58 (77.3) | 50 (80.7) | 50 (71.4) |
RA duration, years | 0.7 (0.2) | 3.1 (1.3) | 7.1 (1.3) | 19.1 (8.0) | 9.3 (10.4) | 11.3 (9.3) | 12.6 (7.5) |
Prior DMARD treatments† | 1.4 (0.5) | 2.0 (1.2) | 2.1 (1.3) | 2.7 (1.6) | 1.0 (0) | 2.0 (0) | 4.0 (1.1) |
DAS28(CRP) | 6.4 (1.1) n=8 | 5.6 (0.8) n=46 | 5.7 (0.9) n=29 | 5.8 (0.7) n=69 | 5.7 (0.9) n=54 | 5.8 (0.8) n=47 | 5.7 (0.8) n=51 |
SDAI | 49.0 (17.2) n=8 | 38.5 (11. 8) n=46 | 40.1 (13.1) n=29 | 41.6 (11.1) n=69 | 40.0 (12.1) n=54 | 41.9 (12.0) n=47 | 40.6 (12.5) n=51 |
HAQ-DI | 1.6 (0.9) n=8 | 1.3 (0.7) n=46 | 1.3 (0.6) n=29 | 1.5 (0.6) n=69 | 1.4 (0.7) n=54 | 1.4 (0.6) n=47 | 1.4 (0.7) n=51 |
*Values are means (SD) unless specified otherwise.
†Including methotrexate.
DAS28(CRP), 28-joint Disease Activity Score based on C-reactive protein; DMARD, disease-modifying antirheumatic drug; HAQ-DI, Health Assessment Questionnaire Disability Index; MTX, methotrexate; RA, Rheumatoid arthritis; SDAI, Simplified Disease Activity Index.