Table 2

Multivariate logistic regression analysis for organ severity accrual

FeaturesOR (95% CI)Organ/system severity accrualP valuez score
Adjusted mean EUSTAR-AI1.43 (1.23 to 1.66)ΔMedsger’s severity score ≥10,0029.49
Adjusted mean ESScG-AI0.98(0.75 to 1.28)0.920.007
Age1.00 (0.99 to1.02)0.320.95
ESR >251.01 (0.59 to 1.73)0.950.003
Anti-Scl-70 Ab1.51 (0.94 to2.44)0.082.96
Subset diffuse0.80 (0.48 to 1.31)0.380.76
Adjusted mean EUSTAR-AI1.23 (1.06 to 1.42)ΔLung severity score ≥10.0067.45
Adjusted mean ESScG-AI1.09 (0.83 to 1.43)0.110.44
Basal lung severity0.57 (0.35 to 0.92)0.010,006
Anti-Scl-70 Ab1.27(0.75 to 2.15)0.350.84
Subset diffuse0.79 (0.46 to 1.36)0.400.69
Adjusted mean EUSTAR-AI1.96(1.10 to 3.50)ΔHeart severity score ≥10.025.20
Adjusted mean ESScG-AI0.52 (0.24 to 1.12)0.092.75
Age1.02 (0.98 to 1.07)0.261.24
RNA polymerase III Ab5.56 (0.65 to 6.98)0.112.48
Subset diffuse0.24 (0.04 to 1.42)0.112.45
Basal vascular severity1.08 (0.28 to 4.16)0.900.01
Basal joint severity2.71 (0.69 to 10.70)0.152.04
Basal lung severity1.04 (0.26 to 4.01)0.953
Adjusted mean EUSTAR-AI1.48 (1.21to1.82)ΔSkin severity score ≥10,000214.29
Age0.97 (0.95 to 0.99)0.0034.40
Baseline skin severity0.21 (0.09 to 0.47)0.000214.27
Adjusted mean ESScG-AI1.34 (0.90 to 2.00)0.132.17
Anti-Scl-70 Ab2.16 (0.85 to 5.50)0.102.65
Adjusted mean EUSTAR-AI1.31 (1.13 to 1.52)ΔPeripheral vascular severity score ≥10.00025.18
Adjusted mean ESScG-AI1.02 (0.76 to 1.37)0.870.02
Basal lung severity1.94 (1.03 to 3.64)0.034.26
Basal vascular severity0.23 (0.13 to 0.39)<0.000129.61
Anti-Scl-70 Ab1.46 (0.75 to 2.48)0.261.24
Subset diffuse1.36 (0.74 to 2.48)0.301.02
Adjusted mean EUSTAR-AI0.86 (0.45 to 1.64)ΔMuscle severity score ≥10.660.19
Adjusted mean ESScG-AI1.49 (0.66 to 3.34)0.330.94
Subset diffuse0.69 (0.12 to 3.81)0.670.17
RNA polymerase III Ab8.32 (1.21 to 6.88)0.034.66
Adjusted mean EUSTAR-AI1.21 (0.15 to 9.32)ΔKidney severity score ≥10.850.03
Adjusted mean ESScG-AI1.24 (0.19 to 7.89)0.590.28
Adjusted mean EUSTAR-AI1.20 (0.40 to 3.53)ΔGI tract severity score ≥10.730.11
Adjusted mean ESScG-AI1.37 (0.32 to 5.76)0.660.18
  • ESR, erythrocyte sedimentation rate; ESScG-AI, European Scleroderma Study Group Activity Index; EUSTAR-AI, European Scleroderma Trials and Research Group Activity Index; GI, gastrointestinal.