Table 1

G-CAN endorsed labels and definitions of the disease elements of gout7

Consensus labelConsensus definition
Chemical elements1. MSU crystalsThe pathogenic crystals in gout (chemical formula: C5H4N4NaO3)
2. UrateThe circulating form of the final enzymatic product generated by xanthine oxidase in purine metabolism in humans (chemical formula: C5H3N4O3)
3. Hyperuricaemia*Elevated blood urate concentration over the saturation threshold
Clinical elements4. Gout flareA clinically evident episode of acute inflammation induced by MSU crystals
5. Intercritical goutThe asymptomatic period after or between gout flares, despite the persistence of MSU crystals
6. Chronic gouty arthritisPersistent joint inflammation induced by MSU crystals
6a. G-CAN recommendationThe label ‘chronic gout’ should be avoided
7. TophusAn ordered structure of MSU crystals and the associated host tissue response
8. Subcutaneous tophusA tophus that is detectable by physical examination
9. PodagraA gout flare at the first metatarsophalangeal joint
Imaging elements10. Imaging evidence of MSU crystal depositionFindings that are highly suggestive of MSU crystals on an imaging test
11. Gouty bone erosionEvidence of a cortical break in bone suggestive of gout (overhanging edge with sclerotic margin)
  • *In British English, hyperuricaemia.

  • G-CAN, Gout, Hyperuricaemia and Crystal-Associated Disease Network; MSU, monosodium urate.