Oral MTX dose (mg/week) and MTX adherence limit (nm) with >80% proportion of subjects who are adherent according to the 1000 hypothetical subjects ingesting MTX 168 hours prior to blood sampling
| MTX dose (mg/week) | Adherence limit (nM) |
| 5 | 0.1 |
| 7.5 | 0.15 |
| 10 | 0.2 |
| 12.5 | 0.25 |
| 15 | 0.25 |
| 17.5 | 0.25 |
| 20 | 0.25 |
| 22.5 | 0.5 |
| 25 | 0.5 |
MTX, methotrexate.