Table 4

Results from the eQTM analysis using the 147 CpGs significantly different in children born to mothers with RA (FEPRA study)

CpGBeta*SE*P value*Nearest genesBeta GN†SE GN†P value GN†Genes GN†
cg213849710.0290.0043.86×10−13 COPZ2 −0.0730.0391.79×10−06 COPZ2
cg112206630.0230.0031.68×10−11 ADD2 −0.1210.0393.32×10−06 ADD2
  • The positive betas in column ‘Beta’ represent hypermethylation, while the negative betas in column ‘Beta GN’ represent decreased gene expression.

  • *The columns beta, SE, p value and nearest genes represent the results from the analysis of DNA methylation in children born to mothers with RA (FEPRA study) as compared with children born to mothers from the general population (Generation R Study).

  • †The columns beta GN, SE GN, p value GN and genes GN represent the results from the BIOS eQTM lookup browser.

  • CpG, cytosine-phosphate-guanine; eQTM, expression quantitative trait methylation; FEPRA, FEtal Programming in Rheumatoid Arthritis; GN, GeneNetwork; RA, rheumatoid arthritis.