Table 3

SNPs in IL10 are associated with transitioning to SLE

GeneSNPMinor alleleMAFTransitioned to SLE (n=52) versus non-transitioned relatives (n=354)
OR (95% CI) p value
Transitioned (n=52) to SLE versus unaffected controls (n=115)
OR (95% CI) p value
IL10 rs3024505T0.14 2.15 (1.31 to 3.53) 0.002 1.87 (1.03 to 3.39) 0.04
IL10 rs3024495A0.15 2.13 (1.31 to 3.45) 0.002 2.00 (1.09 to 3.65) 0.02
IL10 rs3024493T0.14 2.06 (1.25 to 3.37) 0.004 1.91 (1.05 to 3.50) 0.03
IL10 rs1800896C0.451.15 (0.77 to 1.72) 0.501.23 (0.74 to 2.06) 0.43
IL10 rs3122605G0.13 1.86 (1.08 to 3.21) 0.02 1.79 (0.98 to 3.27) 0.06
CD40 rs1569723G0.430.98 (0.72 to 1.33) 0.910.86 (0.59 to 1.23) 0.40
CD40 rs1883832A0.241.02 (0.62 to 1.68) 0.931.11 (0.63 to 1.94) 0.73
CD40 rs4810485A0.250.95 (0.57 to 1.59) 0.851.03 (0.59 to 1.80) 0.90
CR2 rs17615T0.310.97 (0.61 to 1.53) 0.880.72 (0.42 to 1.24) 0.24
TNFAIP3 rs5029930C0.141.41 (0.78 to 2.55) 0.251.49 (0.79 to 2.81) 0.22
TNFAIP3 rs5029939G0.051.19 (0.572.49) 0.651.96 (0.82 to 4.68) 0.13
  • Statistically significant values (p<0.05) are in bold.

  • MAF, minor allele frequency; SLE, systemic lupus erythematosus; SNP, single nucleotide polymorphism.