Table 3

CpGs that were differentially methylated in the same direction in both blood and in buccal epithelial cells

CpGBeta*SEP valueNearest gene (±bp)ChrbpLocation†
cg229982060.10290.0224.40×10−06 1249 239 429
cg036541060.07270.0169.50×10−06 1949 539 527
cg02613964−0.0580.0147.57×10−05 344 690 321
cg11336323−0.0920.0241.63×10−04 1941 946 040Promoter
  • *Beta represents the difference in DNA methylation at the given CpG site in buccal epithelial cells from children born to mothers with RA (FEPRA study) as compared with blood samples from children born to mothers from the general population (Generation R Study).

  • †Location in promoter, gene, enhancer or unknown (–).

  • bp, base pair; Chr, chromosome; CpG, cytosine-phosphate-guanine; FEPRA, FEtal Programming in Rheumatoid Arthritis; RA, rheumatoid arthritis.