Interactions between gender, Porphyromonas gingivalis infection and radiological progression of American College of Rheumatology/European League Against Rheumatism 2010 patients with early rheumatoid arthritis in the ESPOIR cohort
| N=533 | Non-smoking (N=287) | Smoking (N=246) | OR (95% CI), p value | ||
| Negative P. gingivalis serology (N=399) | No radiological progression | 43 (8) | 45 (8) | 0.79 (0.49 to 1.27), 0.336 | 0.94 (0.63 to 1.40), 0.763 |
| Radiological progression | 170 (32) | 141 (27) | |||
| Positive P. gingivalis serology (N=133) | No radiological progression | 19 (4) | 17 (3) | 0.90 (0.41 to 0.77), 0.767 | |
| Radiological progression | 54 (10) | 43 (8) | |||
| Mantel-Haenszel test, p=0.384 | |||||
| Men (N=116) | No radiological progression | 9 (2) | 11 (2) | 1.8 (0.67 to 4.80), 0.238 | 0.34 (0.22 to 0.53), <0.001 |
| Radiological progression | 30 (6) | 66 (12) | |||
| Women (N=417) | No radiological progression | 53 (10) | 51 (10) | 0.62 (0.40 to 0.98), 0.042 | |
| Radiological progression | 195 (36) | 118 (22) | |||
| Mantel-Haenszel test, p=0.201 | |||||
Data are presented as number (%) and mean (95% CI).
P. gingivalis antibodies were measured using a homemade ELISA as previously described.2 Patients were considered P. gingivalis positive when their anti-P. gingivalis antiobody titre was above the higher quartile.
Radiological progression was defined as a progression ≥1 point/year of modified Sharp/van der Heijde score within the first 5 years of follow-up.