Table 1

Shifts in taxonomic abundance in SLE by disease activity

Taxonomic levelTaxonomyHealthy (%)SLEDAIlow (%)SLEDAIhigh(%)P value
Class Erysipelotrichi 1.371.445.920.086
Order Erysipelotrichales 1.371.445.920.086
Family Erysipelotrichaceae 1.371.445.920.086
Family Veillonellaceae 1.583.4112.270.008
Family Ruminococcaceae 25.6611.6815.110.045
Species Ruminococcus gnavus
Species Bacteroides uniformis 2.110.870.340.014
Species Bacteroides fragilis 1.172.412.200.081
  • Results from univariate Kruskal-Wallis ANOVA analysis of 16S rRNA abundance for all taxa across all subjects for p<0.10 and not FDR corrected. The same bacterial set is identified as Erysipelotrichi, Erysipelotrichales and Erysipelotrichaceae. SLEDAIlow patients have SLEDAI scores of less than 8. For the complete analysis, see online supplementary table 2.

  • ANOVA, analysis of variance; SLE, systemic lupus erythematosus; SLEDAI, SLE disease activity index.