Table 2

ICD blocks associated with significant HRs for patients with CHB

ICD
chapter*
ICD blockHR
(95% CI)
Q-valueIncidence rate per 1,000 person-years (95% CI)No. events(%)
Patients with CHB†Controls‡Patients with CHB†Controls‡
IOther bacterial diseases (A30–A49)7.6 (3.2 to 18.1)<0.014.6 (2.4 to 8.9)0.6 (0.3–1.1)9 (7.6%)12 (1.0%)
IOther infectious diseases (B99–B99)9.9 (2.5 to 39.7)0.052.0 (0.7 to 5.3)0.2 (0.1–0.5)4 (3.4%)4 (0.3%)
IIICertain disorders involving the immune mechanism (D80–D89)14.8 (2.5 to 88.4)0.111.5 (0.5 to 4.6)0.1 (0.0–0.4)3 (2.5%)2 (0.2%)
IVMetabolic disorders (E70–E90)4 (1.6 to 10.3)0.133.0 (1.4 to 6.7)0.8 (0.5–1.2)6 (5.0%)15 (1.3%)
VDisorders of psychological development (F80–F89)5.0 (1.7 to 14.6)0.112.5 (1.0 to 6.0)0.5 (0.3–0.9)5 (4.2%)10 (0.8%)
IXOther forms of heart disease (I30–I52)>100 (191.4 to 690.2)<0.01203.5 (169.6 to 244.1)0.7 (0.5–1.2)116 (97.5%)15 (1.3%)
IXCerebrovascular diseases (I60–I69)10.1 (2.5 to 40.2)0.052.0 (0.7 to 5.3)0.2 (0.1–0.5)4 (3.4%)4 (0.3%)
IXDiseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified (I80–I89)3.9 (1.7 to 8.8)0.054.1 (2.0 to 8.1)1.1 (0.7–1.6)8 (6.7%)21 (1.8%)
XAcute upper respiratory infections
(J00–J06)
2.2 (1.4 to 3.3)0.0215.1 (10.3 to 22.0)6.8 (5.7–8.1)27 (22.7%)129 (10.8%)
XInfluenza and pneumonia (J09–J18)4.3 (2.2 to 8.2)<0.016.7 (3.9 to 11.6)1.6 (1.1–2.2)13 (10.9%)31 (2.6%)
XOther acute lower respiratory infections
(J20–J22)
3.8 (1.8 to 8.2)0.044.6 (2.4 to 8.8)1.2 (0.8–1.8)9 (7.6%)24 (2.0%)
XIOther diseases of the digestive system
(K90–K93)
4.4 (1.7 to 11.4)0.103.1 (1.4 to 6.8)0.7 (0.4–1.2)6 (5.0%)14 (1.2%)
XIIInfections of the skin and subcutaneous tissue (L00–L08)5.7 (3.0 to 11.0)<0.017.1 (4.2 to 12.0)1.3 (0.8–1.9)14 (11.8%)25 (2.1%)
XIIOther disorders of the skin and subcutaneous tissue (L80–L99)3.5 (1.6 to 7.9)0.094.0 (2.0 to 8.0)1.2 (0.8–1.7)8 (6.7%)23 (1.9%)
XIIISystemic connective tissue disorders
(M30–M36)
11.8 (4.0 to 35.1)<0.013.5 (1.7 to 7.4)0.3 (0.1–0.7)7 (5.9%)6 (0.5%)
  • *I Certain infectious and parasitic diseases, III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism, IV Endocrine, nutritional and metabolic diseases, IV Endocrine, nutritional and metabolic diseases, V Mental and behavioral disorders, IX Diseases of the circulatory system, X Diseases of the respiratory system, XI Diseases of the digestive system, XII Diseases of the skin and subcutaneous tissue, XIII Diseases of the musculoskeletal system and connective tissue, XIII Diseases of the musculoskeletal system and connective tissue.

  • †Patients with CHB, n=119.

  • ‡General population comparators, n=1,190.

  • CHB, congenital heart block; ICD, International Classification of Diseases.