ICD chapter* | ICD block | HR (95% CI) | Q-value | Incidence rate per 1,000 person-years (95% CI) | No. events(%) | ||
Patients with CHB† | Controls‡ | Patients with CHB† | Controls‡ | ||||
I | Other bacterial diseases (A30–A49) | 7.6 (3.2 to 18.1) | <0.01 | 4.6 (2.4 to 8.9) | 0.6 (0.3–1.1) | 9 (7.6%) | 12 (1.0%) |
I | Other infectious diseases (B99–B99) | 9.9 (2.5 to 39.7) | 0.05 | 2.0 (0.7 to 5.3) | 0.2 (0.1–0.5) | 4 (3.4%) | 4 (0.3%) |
III | Certain disorders involving the immune mechanism (D80–D89) | 14.8 (2.5 to 88.4) | 0.11 | 1.5 (0.5 to 4.6) | 0.1 (0.0–0.4) | 3 (2.5%) | 2 (0.2%) |
IV | Metabolic disorders (E70–E90) | 4 (1.6 to 10.3) | 0.13 | 3.0 (1.4 to 6.7) | 0.8 (0.5–1.2) | 6 (5.0%) | 15 (1.3%) |
V | Disorders of psychological development (F80–F89) | 5.0 (1.7 to 14.6) | 0.11 | 2.5 (1.0 to 6.0) | 0.5 (0.3–0.9) | 5 (4.2%) | 10 (0.8%) |
IX | Other forms of heart disease (I30–I52) | >100 (191.4 to 690.2) | <0.01 | 203.5 (169.6 to 244.1) | 0.7 (0.5–1.2) | 116 (97.5%) | 15 (1.3%) |
IX | Cerebrovascular diseases (I60–I69) | 10.1 (2.5 to 40.2) | 0.05 | 2.0 (0.7 to 5.3) | 0.2 (0.1–0.5) | 4 (3.4%) | 4 (0.3%) |
IX | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified (I80–I89) | 3.9 (1.7 to 8.8) | 0.05 | 4.1 (2.0 to 8.1) | 1.1 (0.7–1.6) | 8 (6.7%) | 21 (1.8%) |
X | Acute upper respiratory infections (J00–J06) | 2.2 (1.4 to 3.3) | 0.02 | 15.1 (10.3 to 22.0) | 6.8 (5.7–8.1) | 27 (22.7%) | 129 (10.8%) |
X | Influenza and pneumonia (J09–J18) | 4.3 (2.2 to 8.2) | <0.01 | 6.7 (3.9 to 11.6) | 1.6 (1.1–2.2) | 13 (10.9%) | 31 (2.6%) |
X | Other acute lower respiratory infections (J20–J22) | 3.8 (1.8 to 8.2) | 0.04 | 4.6 (2.4 to 8.8) | 1.2 (0.8–1.8) | 9 (7.6%) | 24 (2.0%) |
XI | Other diseases of the digestive system (K90–K93) | 4.4 (1.7 to 11.4) | 0.10 | 3.1 (1.4 to 6.8) | 0.7 (0.4–1.2) | 6 (5.0%) | 14 (1.2%) |
XII | Infections of the skin and subcutaneous tissue (L00–L08) | 5.7 (3.0 to 11.0) | <0.01 | 7.1 (4.2 to 12.0) | 1.3 (0.8–1.9) | 14 (11.8%) | 25 (2.1%) |
XII | Other disorders of the skin and subcutaneous tissue (L80–L99) | 3.5 (1.6 to 7.9) | 0.09 | 4.0 (2.0 to 8.0) | 1.2 (0.8–1.7) | 8 (6.7%) | 23 (1.9%) |
XIII | Systemic connective tissue disorders (M30–M36) | 11.8 (4.0 to 35.1) | <0.01 | 3.5 (1.7 to 7.4) | 0.3 (0.1–0.7) | 7 (5.9%) | 6 (0.5%) |
*I Certain infectious and parasitic diseases, III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism, IV Endocrine, nutritional and metabolic diseases, IV Endocrine, nutritional and metabolic diseases, V Mental and behavioral disorders, IX Diseases of the circulatory system, X Diseases of the respiratory system, XI Diseases of the digestive system, XII Diseases of the skin and subcutaneous tissue, XIII Diseases of the musculoskeletal system and connective tissue, XIII Diseases of the musculoskeletal system and connective tissue.
†Patients with CHB, n=119.
‡General population comparators, n=1,190.
CHB, congenital heart block; ICD, International Classification of Diseases.