Table 4

Three-character ICD codes within blocks in table 2 associated with significant hazard ratios for patients with CHB

ICD blockThree-character ICD codeHR
(95% CI)
Q-valueIncidence rate per 1,000 person-years (95% CI)No events
n (%)
Patients with CHB*Controls†Patients with CHB*Controls†
Other bacterial diseasesOther sepsis (A41)>100 (N/A‡)<0.012.5 (1.0 to 6.0)05 (4.2)0 (0)
Bacterial infection of unspecified site (A49)14.9 (2.5–89.1)0.051.5 (0.5 to 4.6)0.1 (0.0–0.4)3 (2.5)2 (0.2)
Disorders of psycho-logical developmentPervasive developmental disorders (F84)7.4 (1.7–33.2)0.111.5 (0.5 to 4.6)0.2 (0.1–0.5)3 (2.5)4 (0.3)
Other forms of heart diseaseCardiomyopathy (I42)>100 (N/A‡)<0.017.1 (4.2 to 12.0)014 (11.8)0 (0)
Atrioventricular and left bundle-branch block (I44)>100 (N/A‡)<0.01195.6 (162.7 to 235.2)0113 (95)0 (0)
Other conduction disorders (I45)>100 (N/A‡)<0.018.8 (5.4 to 14.3)016 (13.4)0 (0)
Paroxysmal tachycardia (I47)51.0 (6.0–436.4)<0.012.5 (1.1 to 6.1)0.0 (0.0–0.4)5 (4.2)1 (0.1)
Atrial fibrillation and flutter (I48)46.7 (10.1–216.1)<0.014.6 (2.4 to 8.8)0.1 (0.0–0.4)9 (7.6)2 (0.2)
Other cardiac arrhythmias (I49)>100 (66.0–415.0)<0.0152.4 (40.2 to 68.3)0.2 (0.1–0.6)55 (46.2)5 (0.4)
Heart failure (I50)34.4 (9.5–125.2)<0.015.1 (2.7 to 9.4)0.1 (0.0–0.5)10 (8.4)3 (0.3)
Cerebrovascular diseasesCerebral infarction (I63)39.9 (4.5–357.3)0.022.0 (0.7 to 5.3)0.0 (0.0–0.4)4 (3.4)1 (0.1)
Acute upper respiratory infectionsAcute tonsillitis (J03)3.7 (1.8–7.7)<0.015.1 (2.8 to 9.5)1.4 (0.9–2.0)10 (8.4)27 (2.3)
AcuteAcute upper respiratory infections of multiple and unspecified sites (J06)2.3 (1.3–4.0)0.048.5 (5.2 to 13.9)3.6 (2.9–4.6)16 (13.4)71 (6)
Influenza and pneumoniaBacterial pneumonia, not elsewhere classified (J15)3.6 (1.3–9.9)0.182.5 (1.0 to 6.0)0.7 (0.4–1.2)5 (4.2)14 (1.2)
pneumoniaPneumonia, organism unspecified (J18)6.4 (2.5–16.5)<0.013.5 (1.7 to 7.4)0.5 (0.3–1.0)7 (5.9)11 (0.9)
Other acute lower respiratory infectionsAcute bronchitis (J20)9.2 (3.7–22.6)<0.014.6 (2.4 to 8.8)0.5 (0.3–0.9)9 (7.6)10 (0.8)
Infections of the skin and subcutaneous tissueOther local infections of skin and subcutaneous tissue (L08)20.1 (6.1–66.9)<0.014.0 (2.0 to 8.0)0.2 (0.1–0.5)8 (6.7)4 (0.3)
Other disorders of the skin and subcutaneous tissueAtrophic disorders of skin (L90)8.0 (2.2–29.9)0.032.0 (0.7s to 5.3)0.2 (0.1–0.6)4 (3.4)5 (0.4)
Systemic connective tissue disordersOther systemic involvement of connective tissue (M35)7.5 (1.7–33.4)0.111.5 (0.5 to 4.6)0.2 (0.1–0.5)3 (2.5)4 (0.3)
  • *Patients with CHB, n=119.

  • †General population comparators, n=1,190.

  • ‡Confidence intervals not enclosed when no events were observed in either cases or controls.