Table 3

HR and incidence of disease for siblings of patients with CHB in ICD blocks associated with significant HRs for patients with CHB

ICD
Chapter*
ICD BlockHR
(95% CI)
Incidence rate per 1,000 person-years (95% CI)No. events(%)
Siblings†Controls‡Siblings†Controls‡
IOther bacterial diseases (A30-A49)1.2 (0.3–5.4)0.9 (0.2 to 3.4)0.8 (0.5–1.3)2 (1.6)15 (1.4)
IOther infectious diseases (B99-B99)<0.01 (N/A§)00.1 (0.0–0.4)0 (0)1 (0.1)
IIICertain disorders involving the immune mechanism (D80-D89)<0.01 (N/A§)00.2 (0.0–0.5)0 (0)3 (0.3)
IVMetabolic disorders (E70-E90)1.5 (0.4–5.3)1.3 (0.4 to 4.0)0.9 (0.6–1.5)3 (2.3)18 (1.7)
VDisorders of psychological development (F80-F89)1.3 (0.3–5.7)0.9 (0.2 to 3.4)0.8 (0.5–1.3)2 (1.6)16 (1.5)
IXOther forms of heart disease (I30-I52)3.0 (1.0–8.9)2.2 (0.9 to 5.2)0.6 (0.3–1.0)5 (3.9)11 (1)
IXCerebrovascular diseases (I60-I69)1.4 (N/A¶)0.4 (0.1 to 3.0)0.3 (0.1–0.6)1 (0.8)5 (0.5)
IXDiseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified (I80-I89)0.5 (0.1–2.0)0.9 (0.2 to 3.4)1.6 (1.1–2.3)2 (1.6)31 (2.9)
XAcute upper respiratory infections
(J00-J06)
0.7 (0.4–1.3)5.3 (3.0 to 9.3)7.7 (6.5–9.1)12 (9.4)141 (13.2)
XInfluenza and pneumonia (J09-J18)1.1 (0.4–3.2)1.7 (0.6 to 4.6)1.4 (0.9–2.0)4 (3.1)27 (2.5)
XOther acute lower respiratory infections
(J20-J22)
0.6 (0.1–2.8)0.9 (0.2 to 3.4)1.2 (0.8–1.8)2 (1.6)24 (2.2)
XIOther diseases of the digestive system
(K90-K93)
1.3 (0.3–5.1)1.3 (0.4 to 4.0)0.9 (0.5–1.4)3 (2.3)17 (1.6%)
XIIInfections of the skin and subcutaneous tissue (L00-L08)1.2 (0.3–3.9)1.3 (0.4 to 4.0)1.3 (0.9–1.9)3 (2.3%)25 (2.3)
XIIOther disorders of the skin and subcutaneous tissue (L80-L99)1.9 (0.7–5.2)2.1 (0.9 to 5.2)1.2 (0.8–1.8)5 (3.9)24 (2.2)
XIIISystemic connective tissue disorders
(M30-M36)
12.7 (N/A¶)1.7 (0.6 to 4.6)0.2 (0.1–0.5)4 (3.1)4 (0.4)
  • *I Certain infectious and parasitic diseases, III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism, IV Endocrine, nutritional and metabolic diseases, IV Endocrine, nutritional and metabolic diseases, V Mental and behavioral disorders, IX Diseases of the circulatory system, X Diseases of the respiratory system, XI Diseases of the digestive system, XII Diseases of the skin and subcutaneous tissue, XIII Diseases of the musculoskeletal system and connective tissue, XIII Diseases of the musculoskeletal system and connective tissue.

  • †Siblings of patients with CHB, n=128.

  • ‡Siblings of general population comparators, n=1,071.

  • §Confidence intervals not enclosed when no events were observed in either cases or controls.

  • ¶In analyses with unmatched samples, confidence intervals were not calculated when the total number of events did not equal or exceed 10.