Table 2

Risk of systemic lupus erythematosus (SLE) in statin users compared with non-statin users aged ≥16 years

SLE
(n)
IR*Age and sex-adjusted
HR (95% CI)
Fully adjusted
HR (95% CI)†
No statin use980.61.001.00
Past statin use241.01.70 (1.08 to 2.66)1.39 (0.86 to 2.23)
Recent statin use211.11.66 (0.99 to 2.78)1.32 (0.76 to 2.28)
Current statin use1240.61.04 (0.78 to 1.38)0.81 (0.57 to 1.15)
≤1 year702.01.43 (0.97 to 2.10)1.12 (0.73 to 1.72)
>1 year540.30.86 (0.62 to 1.21)0.66 (0.44 to 0.98)
  • *Incidence rate is calculated for each recency of statin use by dividing the number of events by the person time within each given recency of use.

  • †Adjusted for age, sex, practice, smoking, cardiovascular diseases, hyperlipidaemia, hypertension, diabetes and use of non-steroid anti-inflammatory drugs.

  • IR, incidence rate (per 10 000 person-years).