Table 1

Overview in history of RA genetics discovery

Publication yearTraitEthnicityApproachRepresentative findings in RA geneticsReference
Around 1980SingleSingleSingle locusIdentification of HLA-DRB1 6
2003SingleSingleEarly GWASIdentification of PADI4 and FCRL3 9 10
2007SingleSingleGWAS with SNP arrayIdentification of TNFAIP3, TRAF1-C5 and STAT4 11–13
2010SingleTransethnicGWAS meta-analysisWorks by RACI, GARNET and immunochip consortia 18–20
2011MultipleSingleGWAS meta-analysisShared risk loci between RA and coeliac disease 32
2014SingleTransethnicGWAS meta-analysisIdentification of >100 RA risk loci 4
2015MultipleSinglePolygenic analysisNegative genetic correlation between RA and SCZ 36 37
FutureMultipleTransethnicPolygenic analysis
  • GARNET, Genetics and Allied research in Rheumatic diseases Networking consortia; GWAS, genome-wide association study; RA, rheumatoid arthritis; RACI, the Rheumatoid Arthritis Consortium International; SCZ, schizophrenia; SNP, single nucleotide polymorphism.