Publication year | Trait | Ethnicity | Approach | Representative findings in RA genetics | Reference |
Around 1980 | Single | Single | Single locus | Identification of HLA-DRB1 | 6 |
2003 | Single | Single | Early GWAS | Identification of PADI4 and FCRL3 | 9 10 |
2007 | Single | Single | GWAS with SNP array | Identification of TNFAIP3, TRAF1-C5 and STAT4 | 11–13 |
2010 | Single | Transethnic | GWAS meta-analysis | Works by RACI, GARNET and immunochip consortia | 18–20 |
2011 | Multiple | Single | GWAS meta-analysis | Shared risk loci between RA and coeliac disease | 32 |
2014 | Single | Transethnic | GWAS meta-analysis | Identification of >100 RA risk loci | 4 |
2015 | Multiple | Single | Polygenic analysis | Negative genetic correlation between RA and SCZ | 36 37 |
Future | Multiple | Transethnic | Polygenic analysis | – | – |
GARNET, Genetics and Allied research in Rheumatic diseases Networking consortia; GWAS, genome-wide association study; RA, rheumatoid arthritis; RACI, the Rheumatoid Arthritis Consortium International; SCZ, schizophrenia; SNP, single nucleotide polymorphism.