Table 3

Median year (IQR) of reported DIL onset for each suspected drug, grouped by decades

1968–19871987–19971997–20072007–2017
Practolol (1976).
Oxprenolol (1977).
Aesculus extract (1976).
Hydralazine, hydrochlorothiazide, reserpine (1982).
Hydralazine (1983).
Procainamide (1985).
Alprenolol (1985).
Methyldopa (1985).		Disopyramide (1988).
Labetalol (1988).
Prazosin (1988).
Tocainide (1988).
Hydrochlorothiazide, methyldopa (1988).
Pindolol (1988).
Hydrochlorothiazide, triamterene (1989).
Quinidine (1989).
Dihydralazine (1989).
Mexiletine (1990).
Propranolol (1991).
Captopril (1992).
Phenelzine (1992).
Fluoxetine (1993).
Gemfibrozil (1993).
1Griseofulvin (1994).
Lovastatin (1994).
Penicillamine (1994).
Acebutolol (1995).
Chlorpromazine (1995).
Felbamate (1995).
Fosinopril (1995).
Cinnarizine (1996).
Nitrofurantoin (1996).
Carbamazepine (1997).
Ethosuximide (1997).
Celiprolol (1997).		Pravastatin (1998).
Altizide, spironolactone (1998).
Carteolol (1998).
Ticlopidine (1998).
Perphenazine (1999).
Valproic acid (1999).
Interferon alpha-2b (2000).
Minocycline (2000).
Phenytoin (2000).
Primidone (2000).
Atenolol (2001).
Bisoprolol, hydrochlorothiazide (2001).
Diltiazem (2001).
Flecainide (2001).
Isoniazid (2001).
Sulfasalazine (2001).
Carbimazole (2002).
Fluvastatin (2002).
Propafenone (2002).
Simvastatin (2003).
Estrogens (2005).
Estrogens conjugated (2005).
Estrogens conjugated, medroxyprogesterone (2005).
Medroxyprogesterone (2005).
Mesalazine (2005).
Terbinafine (2005).
Isotretinoin (2006).
Rofecoxib (2006).
Interferon alpha (2006).		Cyproterone, ethinylestradiol (2008).
Ethinylestradiol, levonorgestrel (2008).
Lamotrigine (2008).
Lansoprazole (2008).
Oxcarbazepine (2008).
Anastrozole (2009).
Efalizumab (2009).
Interferon beta-1b (2009).
Leflunomide (2009).
Propylthiouracil (2009).
Hepatitis b vaccine (2010).
Hydrochlorothiazide, telmisartan (2010).
Infliximab (2010).
Lyme disease vaccine (2010).
Imiquimod (2011).
Nomegestrol (2011).
Romiplostim (2011).
Thiamazole (2011).
Alendronic acid, colecalciferol (2011).
Cetirizine (2011).
Alendronic acid (2012).
Cevimeline (2012).
Esomeprazole (2012).
Hepatitis a vaccine, hepatitis b vaccine (2012).
Interferon beta-1a (2012).
Omeprazole (2012).
Calcium chloride, glucose, magnesium chloride, sodium chloride, sodium lactate (2013).
Ethinylestradiol, etonogestrel (2013).
HPV vaccine (2013).
Teriparatide (2013).
Bosentan (2014).
Etanercept (2014).
Iloprost (2014).
Certolizumab pegol (2014).
Pregabalin (2014).
Adalimumab (2015).
Ambrisentan (2015).
Blood substitutes and perfusion solutions (2015).
Denosumab (2015).
Eculizumab (2015).
Epoprostenol (2015).
Golimumab (2015).
Oxybate sodium (2015).
Treprostinil (2015).
Tocilizumab (2015).
Abatacept (2016).
Corticotropin (2016).
Macitentan (2016).
Desoximetasone (2017).
Folic acid (2017).
Phthalylsulfathiazole (2017).
Riociguat (2017).
Selexipag (2017).

  • Suspected drugs without available median reported onset years are not shown in the table.