Table 3

Performance of SLE-DAS and SLEDAI-2K to detect clinically significant change in SLE disease activity

ΔSLE-DAS≥1.72ΔSLEDAI-2K≥4
SensSpecPPVNPVSensSpecPPVNPV
Derivation cohort
 Clinically meaningful improvement82.196.987.395.444.896.576.987.0
 Clinically meaningful worsening93.197.790.098.546.699.696.489.5
Validation cohort
 Clinically meaningful improvement89.510010098.947.499.49094.5
 Clinically meaningful worsening95.598.287.599.459.199.492.994.9
  • SLE, systemic lupus erythematosus; SLEDAI-2K, SLE Disease Activity Index 2000; SLE-DAS, SLE Disease Activity Score.

  • NPV, negative predictive value (%); PPV: positive predictive value (%); SLE, systemic lupus erythematosus; SLEDAI-2K, SLE Disease Activity Index 2000; SLE-DAS, SLE Disease Activity Score; Sens, sensitivity (%); Spec, specificity (%).