Phenotypic groups of IgG4-RD (derivation cohort)*
| Variables used to identify groups† | Group 1 ‘Pancreato-Hepato-Biliary’ (%) | Group 2 ‘Retroperitoneum and Aorta’ (%) | Group 3 ‘Head and Neck-Limited’ (%) | Group 4 ‘Mikulicz and Systemic’ (%) | P value |
| Pancreas | 87 | 12 | 15 | 46 | <0.001 |
| Liver | 13 | 1 | 2 | 5 | <0.001 |
| Biliary | 55 | <1 | <1 | 27 | <0.001 |
| Orbital | <1 | 3 | 22 | <1 | <0.001 |
| Extraocular muscle | <1 | 1 | 13 | 4 | <0.001 |
| Sinusitis | 3 | <1 | 17 | 16 | <0.001 |
| Parotid gland | 2 | 1 | 22 | 49 | <0.001 |
| Submandibular gland | 15 | 5 | 50 | 77 | <0.001 |
| Lacrimal gland | 3 | 3 | 60 | 48 | <0.001 |
| Renal | 11 | 13 | 5 | 36 | <0.001 |
| Lung | 2 | 15 | 7 | 39 | <0.001 |
| Lymph node | 15 | 25 | 29 | 67 | <0.001 |
| Prostate | 1 | <1 | <1 | 14 | <0.001 |
| Thoracic aorta | 1 | 10 | 1 | 3 | <0.001 |
| Abdominal aorta | 3 | 22 | <1 | 13 | <0.001 |
| Retroperitoneum | 4 | 53 | 2 | 8 | <0.001 |
| Proportion of cohort | 31 | 24 | 24 | 22 | |
| Average probability (Mean) | 93 | 92 | 90 | 90 |
*Only cases (n=478) with complete covariate data are included in the latent class analysis with covariates.
†All percentages are probabilities that the manifestation occurs in that group, conditional on latent class membership (eg, totals will not equal 100%).
IgG4-RD, IgG4-related disease.