Table 1

Clinical and laboratory parameters attributable to systemic lupus erythematosus (SLE), assessed at each outpatient visit

1. ArthritisNumber of swollen joints in 28-joint count.
2. Localized skin rashAcute, subacute and chronic cutaneous lupus rashes included in the SLICC classification criteria, only above the neck.
3. Generalized skin rashAcute, subacute and chronic cutaneous lupus rashes included in the SLICC classification criteria, above and below the neck.
4. AlopeciaAbnormal, patchy or diffuse loss of hair.
5. Mucosal ulcersOral or nasal ulcerations.
6. Systemic vasculitisSystemic vasculitis involving large and medium-sized vessels and lupus enteritis.
7. Mucocutaneous vasculitisAny mucocutaneous vasculitis and chilblain lupus.
8. Neuropsychiatric involvementNeuropsychiatric features included in the SLICC classification criteria for SLE, including recent onset of seizure, psychosis, organic brain syndrome, acute confusional state, SLE retinal changes, peripheral neuropathy, myelopathy, lupus headache, cerebrovascular accident and aseptic meningitis.
9. Cardiac/pulmonary involvementIncluding shrinking lung, interstitial pneumonitis, diffuse alveolar haemorrhage, pulmonary hypertension, myocarditis, valvular dysfunction, Libman-Sacks endocarditis.
10.SerositisIncluding sterile peritonitis in addition to pleurisy and pericarditis.
11.MyositisProximal muscle aching/weakness with elevated CK/aldolase or electromyogram changes or a biopsy showing myositis.
12.ProteinuriaUrinary protein-creatinine ratio (mg/g) or 24 hours urinary protein (mg/24 hours), above 500 mg/g and 500 mg/24 hours, respectively.
13.HypocomplementaemiaDecrease in C3 or C4 below the lower limit of normal for testing laboratory.
14.Increased anti-dsDNAIncrease in DNA binding above the upper limit of normal for testing laboratory.
15.ThrombocytopeniaPlatelet count (10^9/L), below 100x10^9/L platelets.
16.LeucopeniaLeucocyte count (10^9/L), below 3x10^9/L white blood cells.
17. Haemolytic anaemiaAnaemia with positive direct Coombs test, increased serum LDH and low serum haptoglobin.
  • CK, creatine kinase; LDH, lactic dehydrogenase; SLICC, Systemic Lupus International Collaborating Clinics.