Table 5

Selected HLA allele frequencies in African-American patients with AS and controls*

AllelePatients with AS (%)2xN‡Controls (%)2×NORP value†
B*07:003.71347.84900.460.15
B*08:002.21346.14900.350.12
B*14:001.51342.94900.520.56
B*15:0010.513411.04900.940.97
B*27:00 29.9 134 1.0 490 41.3 < 1 × 10 –8
B*35:002.21348.64900.240.02
B*40:003.01341.44902.120.40
B*40:01 3.0 134 0.4 490 7.51 0.03§
B*42:00 3.7 134 10.3 490 0.34 0.03§
B*44:003.01346.94900.410.14
B*51:000.81343.54900.210.17
B*57:003.01344.94900.600.48
B*58:004.51347.84900.560.26
DRB1*01:017.71304.64821.740.23
DRB1*15:01/0313.113011.64821.140.76
DRB1*03:013.11306.24820.480.24
DRB1*03:022.31306.24820.360.13
DRB1*0410.01306.04821.740.16
DRB1*07:003.91307.34820.510.23
DRB1*08:00 10.0 130 5.0 482 2.12 0.05§
DRB1*1112.313012.04821.021.00
DRB1*1321.513019.14821.160.61
DQB1*02:013.11306.6)4820.450.19
DQB1*03:01 27.7 130 19.5 482 1.58 0.05§
DQB1*03:027.71304.84821.660.28
DQB1*04:024.61307.94820.560.28
DQB1*05:0117.713011.64821.640.09
DQB1*06:0216.913013.94821.260.47
DPB1*01:0116.213026.51320.530.06
DPB1*02:0115.413012.11321.320.56
DPB1*03:019.21307.61321.240.80
DPB1*04:0114.61309.11321.710.23
DPB1*04:027.71308.31320.921.00
DPB1*13:016.91303.01322.420.23
DPB1*17:016.913011.21320.590.32
  • Significant associations are highlighted in bold numbers.

  • *Two patients previously typed for HLA-B did not have DNA available for MHC class II typing.

  • †Unless stated, the p-values shown were multiplied by the number of alleles examined at each locus. Alleles with frequencies of <5% were not examined unless potential biological relevance was perceived.

  • ‡After removing the effect of B*27, HLA-B*40:01 occurred in 4 of 94 genotypes in patients compared with 7 of 450 genotypes in controls, p=0.157, OR=3.03.

  • §These represent uncorrected p values. These were no longer significant after applying.Bonferroni’s correction

  • AS, ankylosing spondylitis.