Table 3

HLA-B allele frequency analysis in white patients with AS and controls

AlleleUnivariable modelRel predisp. effectsStratified model
B*27(–)B*27(+)
ORP valuesORP valueORP valueORP values
*07:000.35 < 1 × 10 4 0.70 4 × 10 –4 0.54 < 1 × 10 –2 n/a n/a
*08:00 0.49 <1×104 0.920.450.690.05n/an/a
*13:00 0.60 0.01 1.090.730.900.75n/an/a
*14:001.030.871.842×10–4 1.590.08n/an/a
*15:00 0.43 <1×104 0.820.120.770.232.540.36
*18:000.770.111.350.071.560.07n/an/a
27all 21.48 4×10–287 n/an/an/an/an/an/a
*27:02 10.87 1×10–15 n/an/an/an/an/an/a
*27:04 13.62 3×10–4 n/an/an/an/an/an/a
*27:05 36.46 2×10–275 n/an/an/an/an/an/a
*35:00 0.47 <1×10–4 0.860.201.050.800.470.09
*38:000.920.74 1.73 0.02 2.65 < 1 × 10 –2 0.830.86
*39:00 0.47 < 1 × 10 –3 0.900.731.230.530.360.17
40all 0.71 0.001 1.32 0.02 0.970.891.090.87
*40:011.24 0.16 1.41 0.008 1.510.101.170.80
*40:020.880.690.980.941.620.32n/an/a
*44:00†0.50<1×10–4 1.030.921.040.820.34<1×10–2
*49:00†0.610.071.140.75 2.27 0.03 0.10 < 1 × 10 –4
*50:000.29<1 × 10 –4 0.680.230.860.74n/an/a
*51:00 0.72 0.04 1.280.121.270.351.030.97
*52:001.020.95 1.83 0.05 3.01 < 1 × 10 –2 n/an/a
*57:000.34<1× 10–4 0.620.010.450.030.340.08
  • n/a: OR is not estimable due to frequencies of zero in contingency tables of AS (case/control) and each allele (–/+).

  • Significant associations are highlighted in bold numbers.

  • *The “-co’ nomenclature for B*27 and B40 indicates the grouping of all such 4-digit alleles into 2-digit only.

  • †Significant interaction effect found with B*27 (–/+).

  • AS, ankylosing spondylitis.