Table 4

HLA-B allele frequency analysis in 442 Han Chinese patients with AS and 346 controls

AlleleAS cases %Controls
%
Univariable modelRel predisp. effectsStratified model
ORP valuesORP valueB*27 (–)B*27 (+)
ORP valuesORP values
B*07:00 0.1 1.9 0.06 6.0 × 10 –4 0.11 0.02 0.79 0.82 n/an/a
B*08:000.20.70.310.160.570.78n/an/an/an/a
B*13:004.912.10.38<1×10–4 0.710.100.500.210.800.73
B*14:000.20.12.350.46n/an/an/an/an/an/a
B*15:00 7.7 17.3 0.40 < 1 × 10 –4 0.780.160.700.490.700.50
B*18:000.20.11.570.71n/an/an/an/an/an/a
B*27all 47.6 3.8 23.3 < 1 × 10 –9 n/an/an/an/an/an/a
B*27:04 34.8 2.3 22.6 < 1 × 10 –9 n/a n/an/an/an/an/a
B*27:05 10.9 1.3 9.24 < 1 × 10 –9 n/an/an/an/an/an/a
B*27:15 1.4 0 n/a 0.04 n/an/an/an/an/an/a
B*35:00 1.8 4.5 0.32 < 1 × 10 –3 0.860.200.260.20n/an/a
B*38:001.62.90.530.081.01.01.230.79 0.23 0.03
B*39:001.81.61.260.572.13 0.08 5.12 0.01 0.750.79
B*40all10.512.90.860.38 1.63 0.003 1.900.106.040.08
B*40:016.58.90.840.4 1.41 0.008 2.210.063.230.26
B*40:021.52.50.670.30.980.941.400.66n/an/a
B*44:001.22.30.610.221.001.002.530.170.500.52
B*46:00 4.5 9.8 0.44 < 1 × 10 –3 0.830.440.450.201.190.82
B*50:000.30n/an/an/an/an/an/an/an/a
B*51:00 4.4 8.8 0.47 < 1 × 10 –3 0.910.750.890.812.180.45
B*52:001.72.80.610.151.140.841.090.91n/an/a
B*57:000.60.60.980.971.810.582.640.39n/an/a
B*58:00†3.97.20.520.011.00.981.240.68 0.32 0.03
  • n/a: OR is not estimable due to frequencies of zero in contingency tables of AS (case/control) and each allele (–/+).

  • Significant associations are highlighted in bold numbers.

  • *Significant interaction effect found with B*27 (–/+).

  • †Significant interaction effect found with B*27 (–/+).

  • AS, ankylosing spondylitis.