Table 2

Human inflammatory disease states for which gene editing approaches and therapies have been considered, and for which studies in animal models or primary human cells have been reported

Inflammatory diseaseModelDelivery vector/methodReference
T cells
 Pemphigus vulgarisMurine T cellsLentivirus 70
 Wiskott-Aldrich syndromeHuman HSCRetrovirus 85
Human HSCLentivirus 86 87
 Inflammatory arthritisMurine iPSCsCRISPR/Cas9 via lentivirus 91
 OsteoarthritisMurine iPSCsPlasmid lipofection 61
 Recessive dystrophic epidermolysis bullosaHuman iPSCsPlasmid electroporation 99
 Collagen-induced arthritisMurine T cellsRetrovirus 104
 Rheumatoid arthritisHuman T cellsLentivirus 105
 IPEX syndromeHuman T cellsLentivirus 106
 Graft-versus-host diseaseMurine T cellsRetrovirus 107
 Antigen-induced arthritisMurine T cellsRetrovirus 108
 Type 1 diabetesHuman T cellsLentivirus 110
  • CRISPR, clustered regularly interspaced short palindromic repeat; HSC, haematopoietic stem cell; IPEX, immunodysregulation polyendocrinopathy enteropathy X linked; iPSC, induced pluripotent stem cell.