Table 1

Binding affinity of IV.3 and VIB9600 Fabs to human FcγRIIA

FabAntigenka
(M−1 s−1)
kd
(s−1)
KD
(nM)
IV.3Human FcγRIIa 131 R5.95×106 1.29×10–3 0.22
VIB96004.98×106 7.35×10–4 0.15
IV.3Human FcγRIIa 131 H3.03×106 6.81×10–4 0.22
VIB96002.60×106 3.37×10–4 0.13