Table 1

Predictors of radiographic progression ≥1 unit/year from 0 to 24 months (n=215)

Baseline variables Univariate Multivariate
OR p value OR p value
Age 1.04 (1.02 to 1.07) <0.001 1.02 (1.00 to 1.05)0.09
Gender (female) 0.61 (0.35 to 1.07)0.090.71 (0.36 to 1.37)0.30
Calprotectin quartile (range)
 First quartile (186–556 µg/L)RefRefRefRef
 Second quartile (567–1028 µg/L)1.51 (0.66 to 3.46)0.331.55 (0.60 to 4.01)0.37
 Third quartile (1045–2158 µg/L)1.39 (0.61 to 3.20)0.440.97 (0.36 to 2.60)0.94
 Fourth quartile (2235–48079 µg/L) 6.06 (2.62 to 14.02) <0.001 3.62 (1.20 to 10.93) 0.02
ESR, quartile (range)
 First quartile (1–10 mm/hour)RefRefRefRef
 Second quartile (11–18 mm/hour)1.07 (0.47 to 2.43)0.870.80 (0.31 to 2.04)0.64
 Third quartile (19–31 mm/hour)1.26 (0.55 to 2.86)0.590.82 (0.30 to 2.19)0.69
 Fourth quartile (32–110 mm/hour) 3.74 (1.64 to 8.52) 0.002 0.99 (0.29 to 3.35)0.99
CRP, quartile (range)
 First quartile (0.3–2.8 mg/L)RefRefRefRef
 Second quartile (3–6 mg/L)0.69 (0.29 to 1.64)0.410.41 (0.15 to 1.09)0.07
 Third quartile (7–16 mg/L)1.29 (0.54 to 3.04)0.570.75 (0.25 to 2.19)0.59
 Fourth quartile (18–117 mg/L) 2.85 (1.20 to 6.76) 0.02 0.89 (0.24 to 3.22)0.85
CDAI (0-76) 1.02 (1.00 to 1.04)0.081.01 (0.98 to 1.04)0.50
RF positivity 1.86 (0.99 to 3.48)0.0531.92 (0.91 to 4.06)0.09
vdHS erosion score (0–280) 1.18 (1.07 to 1.29) 0.001 1.14 (1.01 to 1.27) 0.03
  • P values <0.05 in bold.

  • CDAI, Clinical Disease Activity Index; CRP, C reactive protein; ESR, erythrocyte sedimentation rate; h, hour; L, liter; mg, milligram; mm, millimeter; OR, odds ratio; Ref, reference category (lowest quartile as reference); RF, rheumatoid factor; µg, microgram; vdHS, van der Heijde modified Sharp.