Table 5

Proposed domains and items for outcome measures of juvenile idiopathic arthritis (JIA)-associated uveitis (from the Multinational Working Group in JIA-related uveitis)74

DomainsItems
Grade of cells in anterior chamberSlit-lamp examination (according to SUN criteria)
Grade of flare in anterior chamber* Slit-lamp examination for routine clinical practice and prospective trials (according to SUN criteria)
Laser flare photometry for prospective trials
Number of visits with active uveitisRecords of treating physician
  • Duration of activity over a minimum of four visits/year

Visual acuity (appropriate test for age)Best-corrected visual acuity
Thresholds: ≤20/50, ≤20/200 and no light perception
Estimate contribution of amblyopia, yes/no
Development of structural complicationsSynechiae, yes/no
  • Initial and additional

Ocular hypotony, yes/no (<5 mm Hg)
Ocular hypertension, yes/no (>21 mm Hg)
Glaucoma, yes/no
Cataract, yes/no
Band keratopathy in the central cornea, yes/no
Macular oedema by optical coherence tomography, yes/no
  • Funduscopy and optical coherence tomography for routine clinical practice (for macula and optic disc)

  • Funduscopy and optical coherence tomography for prospective trials

Epiretinal membrane formation, yes/no
  • Funduscopy for routine clinical practice

  • Funduscopy and optical coherence tomography for prospective trials

Quality of lifeChildhood Health Assessment Questionnaire
Child Health Questionnaire
Pediatric Quality of Life Inventory
Uveitis-specific quality of life instrument (not yet available for non-English speaking countries)
Overall uveitis-related disabilityAssessment by parents, visual analogue scale
Assessment by children, visual analogue scale
Assessment by treating ophthalmologist, visual analogue scale
Assessment by treating paediatric rheumatologist, visual analogue scale
Social outcomeSchool/kindergarten absence
Anti-inflammatory medication* Reduction of corticosteroid dose—topical dose—systemic dose
Surgery* Yes/no
BiomarkersResearch tools (not currently available
  • *Not an outcome measure, but should be documented.

  • SUN, Standardization of Uveitis Nomenclature.