Table 2

SNP variants associated with stroke/MI

SNPDiscovery cohort
(Sweden)*
Replication cohort
(UCSF)†
Meta-analysis
LocusM/mMAFOR (95% CI)P valuesMAFOR (95% CI)P valuesOR (95% CI)P values
rs17581834IL19C/T0.09/0.042.6 (1.5 to 4.5)7.0×10−4 0.09/0.051.9 (1.05 to 3.6)3.7×10−2 2.3 (1.5 to 3.4)8.5×10−5
rs11119598IL19A/G0.09/0.042.5 (1.5 to 4.4)9.1×10−4 0.09/0.051.9 (1.03 to 3.6)4.1×10−2 2.2 (1.5 to 3.3)1.2×10−4
rs74148801IL19C/T0.09/0.042.5 (1.5 to 4.4)9.1×10−4 0.09/0.051.9 (1.03 to 3.6)4.1×10− 2 2.2 (1.5 to 3.3)1.2×10−4
  • The three SNPs showing an association with stroke and/or MI in both cohorts and in the meta-analysis.

  • *133 patients with and 681 without stroke/MI.

  • †84 patients with and 959 without stroke/MI.

  • SNPs with P<0.001 in the meta-analysis were forwarded for functional analyses.

  • M/m, major/minor alleles; MAF, minor allele frequency for cases/controls; MI, myocardial infarction; P, p value unadjusted; SNP, single nucleotide polymorphisms; UCSF, University of California, San Francisco.