SNP variants associated with stroke/TIA
| SNP | Discovery cohort (Sweden)* | Replication cohort (UCSF)† | Meta-analysis | |||||||
| Locus | M/m | MAF | OR (95% CI) | P values | MAF | OR (95% CI) | P values | OR (95% CI) | P values | |
| rs799454 | SRP54-AS1 | A/G | 0.57/0.40 | 1.8 (1.3 to 2.4) | 2.2×10−4 | 0.50/0.40 | 1.6 (1.03 to 2.3) | 3.4×10−2 | 1.7 (1.3 to 2.2) | 2.5×10−5 |
| rs1712349 | SRP54-AS1 | C/T | 0.56/0.40 | 1.8 (1.3 to 2.4) | 2.2×10−4 | 0.50/0.40 | 1.6 (1.03 to 2.3) | 3.6×10−2 | 1.7 (1.3 to 2.2) | 2.5×10−5 |
| rs712308 | SRP54-AS1 | C/T | 0.56/0.40 | 1.8 (1.3 to 2.4) | 2.2×10−4 | 0.50/0.40 | 1.5 (1.02 to 2.3) | 4.2×10−2 | 1.7 (1.3 to 2.2) | 3.0×10−5 |
| rs11567698 | IL7R | G/T | 0.18/0.11 | 1.8 (1.2 to 2.8) | 3.4×10−3 | 0.18/0.10 | 1.9 (1.1 to 3.1) | 1.6×10−2 | 1.9 (1.3 to 2.5) | 1.5×10−4 |
| rs11567714 | IL7R | C/T | 0.18/0.11 | 1.8 (1.2 to 2.8) | 3.4×10−3 | 0.17/0.10 | 1.9 (1.1 to 3.4) | 3.3×10−2 | 1.9 (1.3 to 2.6) | 2.8×10−4 |
The five SNPs showing an association with stroke and/or TIA in both cohorts.
*96 patients with and 718 without stroke/TIA.
†55 patients with and 988 without stroke; no data regarding TIA in the replication cohort.
SNPs with P<0.001 in the meta-analysis were forwarded for functional analyses.
M/m, major/minor alleles; MAF, minor allele frequency for cases / controls ; P, P value unadjusted; SNP, single nucleotide polymorphisms; TIA, transient ischaemic attack; UCSF, University of California, San Fransisco.