Table 1

Instruments and criteria used for the definition of clinical inactive disease and low (minimal) disease activity in JIA

Items includedRequirements for
classification as CID or LDA
PhGAPa/ChGAAJCESR/CRPSystemic
features
UveitisMorning
stiffness
Criteria for CID
 Wallace’s preliminary criteria4 XXXXX*Normal ESR/CRP and all other items at 0 or not present
 ACR preliminary criteria5 XXXXX†XNormal ESR/CRP, morning stiffness ≤15 min, and all other items at 0 or not present
 JADAS criteria9 XXXXJADAS≤1
 cJADAS criteria11 XXXcJADAS≤1
Criteria for LDA
 Magni-Manzoni criteria—Oligo6 XXPGA≤2.5, AJC=0
 Magni-Manzoni criteria—Poly6 XXXPGA≤3.4, Pa/PtGA≤2.1, AJC≤1‡
 JADAS criteria9 XXXXOligoarticular course: JADAS≤2.0
Polyarticular course: JADAS≤3.8
 cJADAS criteria11 XXXOligoarticular course: cJADAS≤1.5
Polyarticular course: cJADAS≤2.5
  • *Inactive uveitis was not defined.

  • †Inactive uveitis as defined by the Standardization of Uveitis Nomenclature Working Group.

  • ‡In systemic arthritis, absence of systemic features is required.

  • ACR, American College of Rheumatology; AJC, active joint count; CID, clinical inactive disease; cJADAS, clinical JADAS; CRP, C reactive protein; ESR, erythrocyte sedimentation rate; JADAS, Juvenile Arthritis Disease Activity Score; JIA, juvenile idiopathic arthritis; LDA, low disease activity; Oligo, persistent oligoarthritis; Pa/ChGA, parent’s/child’s global assessment of child’s overall well-being; PhGA, physician’s global assessment of overall disease activity; Poly, extended oligoarthritis, polyarthritis and systemic arthritis.