Table 1

Instruments and criteria used for the definition of clinical inactive disease and low (minimal) disease activity in JIA

Items includedRequirements for
classification as CID or LDA
Criteria for CID
 Wallace’s preliminary criteria4 XXXXX*Normal ESR/CRP and all other items at 0 or not present
 ACR preliminary criteria5 XXXXX†XNormal ESR/CRP, morning stiffness ≤15 min, and all other items at 0 or not present
 JADAS criteria9 XXXXJADAS≤1
 cJADAS criteria11 XXXcJADAS≤1
Criteria for LDA
 Magni-Manzoni criteria—Oligo6 XXPGA≤2.5, AJC=0
 Magni-Manzoni criteria—Poly6 XXXPGA≤3.4, Pa/PtGA≤2.1, AJC≤1‡
 JADAS criteria9 XXXXOligoarticular course: JADAS≤2.0
Polyarticular course: JADAS≤3.8
 cJADAS criteria11 XXXOligoarticular course: cJADAS≤1.5
Polyarticular course: cJADAS≤2.5
  • *Inactive uveitis was not defined.

  • †Inactive uveitis as defined by the Standardization of Uveitis Nomenclature Working Group.

  • ‡In systemic arthritis, absence of systemic features is required.

  • ACR, American College of Rheumatology; AJC, active joint count; CID, clinical inactive disease; cJADAS, clinical JADAS; CRP, C reactive protein; ESR, erythrocyte sedimentation rate; JADAS, Juvenile Arthritis Disease Activity Score; JIA, juvenile idiopathic arthritis; LDA, low disease activity; Oligo, persistent oligoarthritis; Pa/ChGA, parent’s/child’s global assessment of child’s overall well-being; PhGA, physician’s global assessment of overall disease activity; Poly, extended oligoarthritis, polyarthritis and systemic arthritis.