Proportion of pregnancies ending in preterm delivery or SGA births based on exposure group and timing of biologic exposure
| Preterm delivery | SGA | |||
| Biologic exposed | Biologic unexposed | Biologic exposed | Biologic unexposed | |
| Overall | 21/120 (18%) | 95/600 (16%) | 11/120 (9%) | 60/600 (10%) |
| Preconception* | 20/114 (18%) | 96/606 (16%) | 11/114 (10%) | 60/606 (10%) |
| First trimester | 18/96 (19%) | 98/624 (16%) | 9/96 (9.4%) | 62/624 (10%) |
| Second trimester | 12/55 (22%) | 104/665 (16%) | 5/55 (9.1%) | 66/665 (10%) |
| Third trimester | 12/57 (21%) | 104/663 (16%) | 5/57 (8.8%) | 66/663 (10%) |
| Unadjusted OR (95% CI) | 1.64 (1.02 to 2.63) | 1.34 (0.72 to 2.51) | ||
| Model 1 OR (95% CI)† | 1.13 (0.67 to 1.90) | 0.91 (0.46 to 1.78) | ||
| Model 2 OR (95% CI)‡ | 1.21 (0.74 to 2.00) | 1.00 (0.53 to 1.92) | ||
| Model 3 OR (95% CI)§ | 0.96 (0.56 to 1.64) | 1.03 (0.53 to 2.01) | ||
| Model 4 OR (95% CI)¶ | 0.94 (0.56 to 1.55) | 1.03 (0.56 to 1.90) | ||
*Defined as 3 months prior to the date of conception.
†Logistic regression in matched cohort.
‡Multivariable logistic regression with HDPS deciles.
§Multivariable logistic regression with continuous HDPS as covariate.
¶Exposure window starting from 12 months preconception, logistic regression in HDPS matched cohort.
HDPS, high-dimensional propensity score; SGA, small-for-gestational-age.