Incidence of flares in SLE pregnancy
| Reference | Country | Pregnancies | Flare definition | Incidence of flare per person-month | ||
| Non-pregnant patients | Pregnancy | Postpartum | ||||
| Mintz et al (1986)29 | Mexico | 102 | Onset of new signs of active disease in a previously inactive organ system, measured by clinical and laboratory variables | 0.04 | 0.06 | – |
| Petri et al (1991)8 | USA | 40 | Change of ≥1.0 in PGA score since the preceding visit or during the last 93 days | 0.05 | 0.14 | 0.05 |
| Wong (1991)13 | China | 29 | Evidence of acute synovitis; pleuritis or pericarditis with radiographic or echocardiographic changes; new neurologic or psychiatric symptoms; thrombocytopenia (<100×109/L); leucopenia (<4×109/L); haemolytic anaemia (positive antiglobulin (Coombs’) test); new cutaneous lesions or active kidney disease (with abnormal urinalysis results, increasing proteinuria and/or low C3 and C4 levels) | 0.04 | 0.08 | – |
| Ruiz-Irastorza et al (1996)9 | UK | 78 | Increase of ≥0.26 or more from the minimum Lupus Activity (LAI) score during follow-up | 0.04 | 0.08 | 0.15 |
| Present analysis | USA | 398 | Change of ≥1.0 in PGA score since the preceding visit | 0.03 | 0.05 | 0.03–0.05 |
| Change of ≥4 in SELENA-SLEDAI score since the preceding visit | 0.04 | 0.05 | 0.04–0.06 | |||
PGA, Physician Global Assessment of disease activity; SLE, systemic lupus erythematosus; SLEDAI, SLE Disease Activity Index.