Chromosome | Position | CpG site | Gene | Interferon induced* | Discovery | Replication | ||
P value† | Methylation Δβ‡ | P value† | Methylation Δβ‡ | |||||
21 | 42799141 | cg21549285 | MX1 | Yes | 3.5E−139 | −0.42 | 6.4E− 83 | −0.47 |
3 | 122281881 | cg22930808 | PARP9 | Yes | 1.4E−105 | −0.27 | 1.2E−74 | −0.33 |
21 | 42797588 | cg22862003 | MX1 | Yes | 2.5E−126 | −0.27 | 1.8E−77 | −0.30 |
1 | 79088769 | cg05696877 | IFI44L | Yes | 1.9E−120 | −0.26 | 4.1E−86 | −0.32 |
1 | 79085586 | cg03607951 | IFI44L | Yes | 3.0E−141 | −0.25 | 4.8E−83 | −0.27 |
10 | 91153143 | cg05552874 | IFIT1 | Yes | 2.5E−128 | −0.25 | 1.8E−73 | −0.27 |
3 | 146260954 | cg06981309 | PLSCR1 | Yes | 4.9E− 157 | −0.24 | 7.6E−91 | −0.25 |
3 | 122281975 | cg00959259 | PARP9 | Yes | 9.3E−105 | −0.23 | 6.1E−71 | −0.27 |
11 | 315102 | cg23570810 | IFITM1 | Yes | 1.6E−5 | −0.20 | 3.4E−60 | −0.24 |
21 | 42797847 | cg26312951 | MX1 | Yes | 1.3E−82 | −0.18 | 1.2E−59 | −0.22 |
22 | 50971140 | cg20098015 | ODF3B | Yes | 7.1E−96 | −0.15 | 1.1E−52 | −0.16 |
2 | 7004578 | cg01028142 | CMPK2 | Yes | 1.2E−64 | −0.15 | 4.5E−47 | −0.19 |
1 | 79085713 | cg17980508 | IFI44L | Yes | 3.8E−179 | −0.14 | 1.1E−79 | −0.13 |
8 | 66751182 | cg14864167 | PDE7A | Yes | 3.6E−41 | −0.14 | 4.0E−37 | −0.20 |
8 | 144099482 | cg17052170 | LOC100133669,LY6E | Yes | 1.5E−58 | −0.13 | 2.6E−35 | −0.15 |
11 | 319667 | cg09122035 | Intergenic | NA | 3.1E−72 | −0.13 | 9.9E−41 | −0.13 |
11 | 319555 | cg20045320 | Intergenic | NA | 1.0E−63 | −0.13 | 8.3E−38 | −0.13 |
11 | 614761 | cg08926253 | IRF7 | Yes | 6.8E−81 | −0.13 | 1.5E−54 | −0.14 |
1 | 79085162 | cg13304609 | IFI44L | Yes | 5.0E−63 | −0.13 | 3.3E−47 | −0.16 |
6 | 35654363 | cg03546163 | FKBP5 | Yes | 1.5E−66 | −0.13 | 1.8E−24 | −0.11 |
22 | 50973101 | cg05523603 | Intergenic | NA | 4.7E−71 | −0.13 | 2.0E−50 | −0.14 |
16 | 87371097 | cg01787084 | FBXO31 | NA | 1.4E−126 | −0.13 | 8.3E−61 | −0.10 |
11 | 315262 | cg03038262 | IFITM1 | Yes | 1.6E−50 | −0.12 | 2.7E−48 | −0.17 |
1 | 79118191 | cg01079652 | IFI44 | Yes | 3.6E−43 | −0.12 | 1.7E−25 | −0.13 |
7 | 2444534 | cg10152449 | CHST12 | Yes | 3.6E−102 | −0.11 | 3.5E−49 | −0.10 |
6 | 29911550 | cg17608381 | HLA-A | Yes | 4.8E−25 | −0.11 | 4.1E−15 | −0.12 |
2 | 7018020 | cg10959651 | RSAD2 | Yes | 2.9E−110 | −0.11 | 3.1E−66 | −0.12 |
11 | 319718 | cg17990365 | IFITM3 | Yes | 9.5E−56 | −0.11 | 1.5E−35 | −0.11 |
1 | 79085765 | cg00855901 | IFI44L | Yes | 1.0E−135 | −0.11 | 2.6E−70 | −0.11 |
2 | 7016509 | cg23213327 | RSAD2 | Yes | 4.7E−92 | −0.10 | 8.0E−58 | −0.10 |
20 | 62204908 | cg01190666 | PRIC285 (HELZ2) | Yes | 1.2E−111 | −0.10 | 5.7E−61 | −0.11 |
3 | 45984838 | cg08450017 | CXCR6,FYCO1 (RUFY3) | Yes | 1.4E− 130 | 0.13 | 1.8E−51 | 0.10 |
DMCs with |Δβ| > 0.1 in both the discovery and replication cohorts are listed.
*Database of interferon-regulated genes http://interferome.org.
†P value for case–control comparison using a linear regression model containing cell count estimates, age and sex as covariates.
‡Difference in average methylation beta value between patients and control individuals.