WT (n=16) | Tg197 (n=19) | P value | |
Body weight (g) | 26.25±1.06 | 16.73±0.091 | <0.0001 |
Heart weight (mg) | 107.10±3.39 | 83.00±5.31 | <0.0001 |
HW/BW (mg/g) | 4.11±0.08 | 5.05±0.27 | 0.0054 |
LVEDd (mm/BW) | 0.14±0.01 | 0.22±0.01 | <0.0001 |
LVEDs (mm/BW) | 0.08±0.01 | 0.14±0.01 | <0.0001 |
LVLd (mm/BW) | 0.28±0.01 | 0.38±0.01 | <0.0001 |
LVPWd (mm/BW) | 0.026±0.001 | 0.038±0.002 | <0.0001 |
IVSd (mm/BW) | 0.026±0.001 | 0.038±0.002 | <0.0001 |
LA (mm/BW) | 0.083±0.003 | 0.132±0.006 | <0.0001 |
SVPW (cm/s) | 3.02±0.08 | 2.14±0.07 | <0.0001 |
E/A ratio | 1.87±0.13 | 1.33±0.09 | 0.0009 |
Values were normalised with the body weight (except for SVPW), as indicated in the table. Data were expressed as mean±SEM.
E/A ratio, ratio between E (peak early diastolic flow) and A (peak late diastolic flow); HW/BW, heart weight-to-body weight ratio; IVSd, end-diastolic interventricular septal thickness; LA, left atrium; LVEDd, left ventricular end-diastolic diameter; LVEDs, left ventricular end-systolic diameter; LVLd, left ventricular length in diastole; LVPWd, left ventricular end-diastolic posterior wall thickness; SVPW: systolic velocity of the posterior wall.