Table 2

Crude incidence rates and adjusted HRs of serious infection events, MI and CHD associated with MBDA score

SIE (primary)
n=16 424 person-years
SIE (primary or secondary)
n=16 320 person-years
MI (primary or secondary)
n=16 072 person-years
CHD (primary or secondary)
n=16 037 person-years
IR (95% CI)aHR (95% CI)IR (95% CI)aHR (95% CI)IR (95% CI)aHR (95% CI)IR (95% CI)aHR (95% CI)
Main analysis in the overall population, MBDA as a continuous score2.75 (2.51 to 3.02)1.32* (1.24 to 1.41)4.00 (3.71 to 4.32)1.34* (1.27 to 1.41)0.82 (0.69 to 0.97)1.09* (0.97 to 1.23)1.13 (0.98 to 1.31)1.09* (0.98 to 1.22)
MBDA score category
 Low (<30)0.74 (0.46 to 1.17)Referent1.19 (0.83 to 1.72)Referent0.42 (0.22 to 0.78)Referent0.67 (0.41 to 1.09)Referent
 Moderate (30-44)1.98 (1.68 to 2.35)2.18 (1.33 to 3.59)2.73 (2.36 to 3.15)1.85 (1.25 to 2.76)0.80 (0.61 to 1.04)1.53 (0.77 to 3.07)1.05 (0.83 to 1.33)1.34 (0.77 to 2.34)
 High (>44)4.17 (3.72 to 4.67)3.56 (2.18 to 5.81)6.17 (5.62 to 6.78)3.34 (2.26 to 4.91)0.98 (0.78 to 1.24)1.52 (0.77 to 3.01)1.36 (1.11 to 1.66)1.42 (0.82 to 2.47)
  • CHD=MI, percutaneous coronary intervention (PCI) or coronary artery bypass graft ing (CABG) .

  • *Per 10 unit change in the MBDA score. The MBDA score ranges from 1 to 100.

  • aHR, adjusted HR, controlling for age, sex and race, acute myocardial infarction, CHD, heart failure, stroke, abdominal aortic aneurysm, peripheral arterial disease, atrial fibrillation, diabetes, hyperlipidaemia, hypertension, obesity, smoking, chronic kidney disease, chronic obstructive pulmonary disease, pneumonia, sepsis, fibromyalgia, peptic ulcer disease, fracture, skin ulcer, prostate-specific antigen, Papanicolaou smear, mammography, use of hydroxychloroquine, leflunomide, sulfasalazine, or biologics, glucocorticoid dose, methotrexate dose, and reason for eligibility for Medicare (eg, disability). The MI and CHD models did not control for prior acute MI or CHD events since these patients were excluded from that outcome.

  • aHR, adjusted HR ; CHD, coronary heart disease; IR, incidence rate per 100 patient years; MBDA, multibiomarker disease activity; MI, myocardial infarction; SIE, serious infection event.