Healthcare costs by MBDA category*
| MBDA score | n* | Baseline 12 month costs, $ Median (IQR) | Incremental healthcare costs compared with baseline, $ Median (IQR)† | |
| All costs‡ | <30 | 1269 | 10 257 (4587–25 421) | −443 (−4194 to 4312) |
| 30–44 | 3904 | 12 480 (5504–28 227) | −243 (−4990 to 6160) | |
| >44 | 4885 | 14 581 (5693–33 006) | 459 (−5320 to 10794) | |
| Medical costs§ | <30 | 1269 | 6804 (3601–16 504) | −192 (−3425 to 3872) |
| 30–44 | 3904 | 8889 (4324–20 854) | 43 (−4255 to 5241) | |
| >44 | 4885 | 11 247 (4522–27 586) | 366 (−5078 to 9729) |
*Analysis conducted among subgroup of patients with 1-year baseline and 1-year follow-up; n values are lower than main cohort because of the latter requirement.
†Calculated as the costs in the year following the first measurement of the MBDA score minus costs in the baseline year.
‡Includes cost from inpatient, outpatient, nursing home, durable medical equipment, home health and part D drug.
§Excluded costs related to parenteral rheumatoid arthritis therapies (eg, intravenous biologics) that bill under Medicare part B.
MBDA, multibiomarker disease activity.