Table 3

Adjusted HRs for MI and CHD associated with MBDA score

aHR (95% CI)aHR (95% CI) adjusted for leptinaHR (95% CI) excluding CRPaHR (95% CI) excluding CRP, adjusted for leptin
MI events
 Quartile 1ReferentReferentReferentReferent
 Quartiles 2–41.52 (0.92 to 2.50)1.65 (1.00 to 2.72)1.70 (1.01 to 2.87)1.86 (1.10 to 3.15)
CHD events
 Quartile 1ReferentReferentReferentReferent
 Quartiles 2–41.54 (1.01 to 2.34)1.64 (1.08 to 2.51)1.53 (1.01 to 2.32)1.64 (1.07 to 2.50)
  • aHR, adjusted HR, controlling for age, sex and race, heart failure, stroke, abdominal aortic aneurysm, peripheral arterial disease, atrial fibrillation, diabetes, hyperlipidaemia, hypertension, obesity, smoking, chronic kidney disease, chronic obstructive pulmonary disease, pneumonia, sepsis, fibromyalgia, peptic ulcer disease, fracture, skin ulcer, prostate-specific antigen, Papanicolaou smear, mammography, use of hydroxychloroquine, leflunomide, sulfasalazine or biologics, glucocorticoid dose, methotrexate dose, and reason for eligibility for Medicare (eg, disability).

  • CHD, coronary heart disease; CRP, C reactive protein; MBDA, multibiomarker disease activity; MI, myocardial infarction.