Table 1

Descriptive baseline characteristics of 5638 patients with RA without prior CVD

CharacteristicsAvailable  (n)Overall (n=5638)Female (n=4278)Male (n=1360)p Value
 Length of follow-up, years56385.8 (4.4)5.8 (4.4)6.0 (4.6)
 Age, years563855.3 (14.0)54.7 (14.4)57.2 (12.7)<0.001
 White race39453699 (94%)2924 (93.4%)775 (95.2%)0.056
RA characteristics
 Calendar year of RA diagnosis56281998.4 (9.9)1998.1 (10.1)1999.2 (9.1)0.007
 RA disease duration, years56286.4 (9.2)6.9 (9.5)4.9 (8.0)<0.001
 RF and/or ACPA positive54853949 (72%)2982 (71.8%)967 (72.7%)0.540
 ESR, mm/hour473724.8 (21.4)25.1 (20.9)23.8 (22.8)<0.001
 C reactive protein, mg/L452815.4 (27.1)13.7 (24.8)21.1 (33.0)<0.001
 DAS2844484.0 (1.7)4.0 (1.7)3.9 (1.7)0.466
Traditional CVD risk factors
 Systolic blood pressure, mm Hg5345136.0 (21.9)134.3 (22.0)141.3 (20.7)<0.001
 Diastolic blood pressure, mm Hg534379.6 (11.1)78.5 (11.0)83.0 (10.7)<0.001
 Total cholesterol, mmol/L44575.2 (1.1)5.2 (1.1)5.1 (1.1)<0.001
 Low density lipoprotein, mmol/L43643.1 (1.0)3.1 (1.0)3.1 (1.0)0.077
 High density lipoprotein, mmol/L44031.5 (0.4)1.5 (0.5)1.3 (0.3)<0.001
 Triglycerides, mmol/L42401.4 (0.8)1.4 (0.7)1.5 (1.0)0.001
 Current smoker53681148 (21%)788 (19.3%)360 (28.1%)0.001
 Ever smoker51202688 (52%)1838 (47.1%)850 (69.7%)<0.001
 Body mass index, kg/m2 516027.0 (5.4)26.9 (5.7)27.2 (4.4)<0.001
 Hypertension56182344 (42%)1726 (40.5%)618 (45.7%)0.001
 Diabetes mellitus5637395 (7%)290 (6.8%)105 (7.7%)0.237
 Family history of CVD3677876 (24%)658 (23.8%)218 (23.9%)0.931
Medication
 Antihypertensives56081314 (23%)1008 (23.7%)306 (22.6%)0.437
 Lipid-lowering therapy5604510 (9%)383 (9.0%)127 (9.4%)0.395
 Synthetic DMARD55932610 (47%)2085 (49.1%)525 (38.9%)<0.001
 Biological DMARD5592891 (16%)762 (18.0%)129 (9.6%)<0.001
 Corticosteroid55901527 (27%)1177 (27.7%)350 (26.0%)0.201
 Corticosteroid dosage, mg/day8695.8 (4.4)5.6 (4.2)6.4 (5.2)0.066
  • Values in table are mean (SD) or n (%).

  • ACPA, anticitrullinated protein antibody; CVD, cardiovascular disease; DAS28, Disease Activity Score including 28 joints; DMARD, disease-modifying antirheumatic drug; ESR, erythrocyte sedimentation rate; RA, rheumatoid arthritis; RF, rheumatoid factor.