Table 2

Differentially expressed miRNAs with p value less than 0.05 in T cells from patients with pSS compared with the controls in the discovery cohort (two different normalisation ways were used: global mean and reference miRNAs)

(pSS TL) vs (ctrl TL)/global mean normalisation			(pSS TL) vs (ctrl TL)/reference miRNAs normalisation			Common miRNAs/global mean and reference miRNAs
miRNAs	Fold change	p Value	miRNAs	Fold change	p Value	Common miRNAs/global mean and reference miRNAs
hsa-let-7d-3p	−2.53	5.07E-07	hsa-let-7d-3p	−2.58	1.97E-07	hsa-let-7d-3p
hsa-miR-28–5 p	1.36	3.78E-05	hsa-miR-28–5 p	1.34	3.81E-04	hsa-miR-28–5 p
hsa-miR-378a-3p	−1.33	7.32E-04	hsa-miR-378a-3p	−1.36	1.15E-04	hsa-miR-378a-3p
hsa-miR-26a-5p	−1.28	9.50E-04	hsa-miR-26a-5p	−1.30	1.23E-03	hsa-miR-26a-5p
hsa-miR-425–3 p	−1.33	1.04E-03	hsa-miR-425–3 p	−1.36	1.09E-03	hsa-miR-425–3 p
hsa-miR-486–5 p	1.56	6.45E-03	hsa-miR-486–5 p	1.53	0.013	hsa-miR-486–5 p
hsa-miR-181c-5p	1.43	7.33E-03	hsa-miR-181c-5p	1.40	0.022	hsa-miR-181c-5p
hsa-miR-30b-5p	−1.17	0.010	hsa-miR-30b-5p	−1.19	0.024	hsa-miR-30b-5p
hsa-miR-140–3 p	1.14	0.013	hsa-miR-140–3 p	1.12	0.043	hsa-miR-140–3 p
hsa-miR-296–5 p	1.27	0.013	hsa-miR-296–5 p	1.25	0.044	hsa-miR-296–5 p
hsa-miR-30c-5p	−1.12	0.014	hsa-miR-30c-5p	−1.14	8.19E-03	hsa-miR-30c-5p
hsa-miR-155–5 p	1.30	0.014	hsa-miR-155–5 p	1.27	0.013	hsa-miR-155–5 p
hsa-miR-31–3 p	−1.43	0.015	hsa-miR-31–3 p	−1.46	0.017	hsa-miR-31–3 p
hsa-miR-598	−1.31	0.015	hsa-miR-598	−1.34	0.017	hsa-miR-598
hsa-miR-222–3 p	1.22	0.018	hsa-miR-222–3 p	1.19	0.046	hsa-miR-222–3 p
hsa-miR-18a-3p	1.37	0.028	hsa-miR-18a-3p	1.34	0.043	hsa-miR-18a-3p
hsa-let-7e-5p	−1.28	0.032	hsa-let-7e-5p	−1.30	0.020	hsa-let-7e-5p
hsa-miR-194–5 p	1.13	0.036
hsa-miR-361–3 p	1.32	0.037
hsa-miR-152	1.32	0.037
hsa-miR-374a-5p	−1.21	0.037	hsa-miR-374a-5p	−1.24	0.041	hsa-miR-374a-5p
hsa-miR-22–3 p	1.34	0.038
hsa-miR-665	−1.42	0.039	hsa-miR-665	−1.44	0.029	hsa-miR-665
hsa-let-7g-5p	1.10	0.039
hsa-let-7i-5p	1.12	0.040
hsa-miR-107	1.18	0.041
hsa-miR-27b-3p	−1.27	0.041	hsa-miR-27b-3p	−1.30	0.034	hsa-miR-27b-3p
hsa-miR-150–5 p	1.15	0.045
hsa-miR-16–5 p	1.14	0.045	hsa-miR-16–5 p	1.12	0.037	hsa-miR-16–5 p
hsa-miR-454–3 p	1.15	0.045
hsa-miR-324–3 p	1.12	0.047
			hsa-miR-23b-3p	−1.22	0.038
			hsa-miR-505–3 p	−1.36	0.044
			hsa-miR-766–3 p	−1.17	0.029

‘MiRNAs in grey’ represent those found differentially expressed by one way of normalisation only. Nominal p values without correction for multiple comparisons are shown.
miRNA, microRNA; pSS, primary Sjögren’s syndrome; TL, T lymphocytes.