Table 3

Differentially expressed miRNAs (p value<0.05) in B cells from patients with pSS compared with the controls in the discovery cohort (two different normalisation ways were used: global mean and reference miRNAs)

(pSS BL) vs (ctrl BL)/global mean normalisation			(pSS BL) vs (ctrl BL)/reference miRNAs normalisation			Common miRNAs/global mean and reference miRNAs
miRNAs	Fold change	p Value	miRNAs	Fold change	p Value	Common miRNAs/global mean and reference miRNAs
hsa-miR-30b-5p	−1.52	4.08E-04	hsa-miR-30b-5p	−1.56	5.01E-03	hsa-miR-30b-5p
hsa-miR-222–3 p	1.46	4.16E-04	hsa-miR-222–3 p	1.43	2.29E-04	hsa-miR-222–3 p
hsa-miR-107	1.35	1.07E-03	hsa-miR-107	1.32	2.35E-03	hsa-miR-107
hsa-miR-18a-3p	1.94	1.79E-03	hsa-miR-18a-3p	1.89	3.51E-03	hsa-miR-18a-3p
hsa-miR-324–5 p	1.64	1.81E-03	hsa-miR-324–5 p	1.6	2.60E-03	hsa-miR-324–5 p
hsa-miR-151a-3p	1.4	1.96E-03	hsa-miR-151a-3p	1.37	4.71E-03	hsa-miR-151a-3p
hsa-miR-324–3 p	1.22	2.21E-03	hsa-miR-324–3 p	1.19	0.026	hsa-miR-324–3 p
hsa-miR-19b-3p	−1.39	3.35E-03	hsa-miR-19b-3p	−1.43	0.014	hsa-miR-19b-3p
hsa-miR-26a-5p	−1.34	5.38E-03	hsa-miR-26a-5p	−1.37	0.016	hsa-miR-26a-5p
hsa-miR-20a-5p	−1.17	5.81E-03	hsa-miR-20a-5p	−1.2	0.014	hsa-miR-20a-5p
hsa-miR-141–3 p	−1.86	6.54E-03	hsa-miR-141–3 p	−1.9	5.64E-03	hsa-miR-141–3 p
hsa-miR-29b-2–5 p	1.39	7.51E-03	hsa-miR-29b-2–5 p	1.35	0.010	hsa-miR-29b-2–5 p
hsa-miR-374a-5p	−1.54	8.90E-03	hsa-miR-374a-5p	−1.58	0.017	hsa-miR-374a-5p
hsa-miR-484	1.45	0.012	hsa-miR-484	1.41	0.019	hsa-miR-484
hsa-miR-195–5 p	−1.57	0.012	hsa-miR-195–5 p	−1.61	0.019	hsa-miR-195–5 p
hsa-miR-210	1.33	0.012	hsa-miR-210	1.3	0.039	hsa-miR-210
hsa-miR-32–5 p	−1.63	0.013	hsa-miR-32–5 p	−1.67	0.027	hsa-miR-32–5 p
hsa-miR-582–5 p	−1.67	0.014	hsa-miR-582–5 p	−1.72	0.018	hsa-miR-582–5 p
hsa-let-7d-3p	−1.65	0.022	hsa-let-7d-3p	−1.7	8.83E-03	hsa-let-7d-3p
hsa-miR-378a-3p	−1.35	0.027	hsa-miR-378a-3p	−1.38	0.020	hsa-miR-378a-3p
hsa-miR-505–3 p	−1.59	0.027	hsa-miR-505–3 p	−1.63	0.020	hsa-miR-505–3 p
hsa-miR-30c-5p	−1.17	0.028
hsa-miR-491–5 p	1.57	0.029	hsa-miR-491–5 p	1.53	0.036	hsa-miR-491–5 p
hsa-miR-502–5 p	1.74	0.029	hsa-miR-502–5 p	1.69	0.048	hsa-miR-502–5 p
hsa-miR-151a-5p	1.2	0.035
hsa-miR-148b-3p	−1.23	0.038	hsa-miR-148b-3p	−1.26	0.012	hsa-miR-148b-3p
hsa-miR-130b-3p	1.47	0.041
hsa-miR-15a-5p	−1.21	0.043
hsa-miR-29b-3p	−1.48	0.044
hsa-miR-296–5 p	1.64	0.044
hsa-miR-142–5 p	−1.53	0.046
			hsa-miR-192–5 p	−1.28	0.048
			hsa-miR-374b-5p	−1.38	0.049

‘MiRNAs in grey’ represents those found differentially expressed by one way of normalisation only. Nominal p-values without correction for multiple comparisons are shown.
BL, B lymphocytes; miRNA, microRNA; pSS, primary Sjögren’s syndrome.