Clinical assessment of axial spondyloarthritis
| BASDAI 62 | Questions | Calculation |
| 1. How would you describe the overall level of fatigue/tiredness you have experienced? | Assess each question on a numerical rating scale (NRS) of 0 (none) to 10 (very severe), alternatively, a VAS can be used for questions 1–5 (NRS preferred by ASAS) Calculation of BASDAI:
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| 2. How would you describe the overall level of ankylosing spondylitis neck, back or hip pain you have had? | ||
| 3. How would you describe the overall level of pain/swelling in joints other than neck, back or hips you had? | ||
| 4. How would you describe the overall level of discomfort you have had from any areas tender to touch or pressure? | ||
| 5. How would you describe the overall level of morning stiffness you have had from the time you wake up? | ||
| 6. How long does your morning stiffness last from the time you wake up? | ||
| ASDAS 84 89 | Parameters | Calculations |
| 1. Total back pain (BASDAI question 2) | ASDAS-CRP: 0.121 x total back pain+0.110 x patient global+0.073 x peripheral pain/swelling+0.058 x duration of morning stiffness+0.579xln(CRP+1); ASDAS-ESR: 0.113xpatient global+0.293x√ESR+0.086 x peripheral pain/swelling+0.069 x duration of morning stiffness+0.079xtotal back pain Assess each question on an NRS of 0 (none) to 10 (very severe) | |
| 2. Patient global assessment | ||
| 3. Peripheral pain/swelling (BASDAI question 3) | ||
| 4. Duration of morning stiffness (BASDAI question 6) | ||
| 5. C reactive protein (CRP) in mg/L (or erythrocyte sedimentation rate (ESR)) (the lowest value for CRP can be 2 mg/L) | ||
| Improvement criteria | ||
| ASAS 2090 | Improvement ≥20% and absolute improvement of ≥1 unit (on a scale of 0–10; or 10 units on a scale of 0–100) in at least three of the four following domains: | |
| Patient global assessment | ||
| Pain | ||
| Function (BASFI)63 | ||
| Inflammation (mean of morning stiffness-related BASDAI VAS scores for questions 5 and 6) | ||
| No worsening of ≥20% and ≥1 unit in the remaining domain | ||
| ASAS 4091 | Improvement ≥40% and absolute improvement of ≥2 unit (on a scale of 0–10; or 10 units on a scale of 0–100) in at least three of the four following domains: | |
| Patient global assessment | ||
| Pain | ||
| Function (BASFI)63 | ||
| Inflammation (mean of morning stiffness-related BASDAI VAS scores for questions 5 and 6) | ||
| No worsening at all in the fourth domain | ||
| Remission criteria | ||
| ASAS partial remission90 | A value not above two units on a 0–10 scale in each of the four domains: patient global, pain, function, inflammation (mean of morning stiffness-related BASDAI VAS scores for questions 5 and 6)* | |
| ASDAS inactive disease84 | ASDAS <1.3 |
ASAS, Assessments of SpondyloArthritis international Society90; ASDAS, Ankylosing Spondylitis Disease Activity Score; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index62; BASFI, Bath Ankylosing Spondylitis Functional Index; VAS, Visual Analogue Scale.