Impact of disease activity statuses on mortality, new damage and severe new damage: univariable and multivariable analyses
| Remission (on/off therapy) | LDAS | |||
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Mortality | ||||
| Unadjusted | 0.46 (0.17 to 1.27) | 0.1330 | 0.65 (0.26 to 1.60) | 0.3454 |
| Adjusted* | 0.56 (0.20 to 1.55) | 0.2623 | 0.81 (0.32 to 2.02) | 0.6476 |
| New damage† | ||||
| Unadjusted | 0.53 (0.38 to 0.75) | 0.0003 | 0.61 (0.44 to 0.85) | 0.0032 |
| Adjusted* | 0.60 (0.43 to 0.85) | 0.0042 | 0.66 (0.48 to 0.93) | 0.0158 |
| Severe new damage‡ | ||||
| Unadjusted | 0.31 (0.15 to 0.64) | 0.0014 | 0.48 (0.26 to 0.92) | 0.0260 |
| Adjusted* | 0.32 (0.15 to 0.68) | 0.0033 | 0.54 (0.28 to 1.03) | 0.0614 |
| New damage (non-GC)§ | ||||
| Unadjusted | 0.45 (0.31 to 0.66) | <0.0001 | 0.56 (0.40 to 0.80) | 0.0013 |
| Adjusted* | 0.51 (0.35 to 0.75) | 0.0006 | 0.62 (0.43 to 0.87) | 0.0067 |
| Severe new damage (non-GC)¶ | ||||
| Unadjusted | 0.25 (0.10 to 0.62) | 0.0028 | 0.30 (0.12 to 0.74) | 0.0091 |
| Adjusted* | 0.31 (0.12 to 0.75) | 0.0101 | 0.35 (0.14 to 0.85) | 0.0206 |
| New damage (GC)** | ||||
| Unadjusted | 1.06 (0.59 to 1.92) | 0.8476 | 1.24 (0.69 to 2.23) | 0.4682 |
| Adjusted* | 0.99 (0.53 to 1.84) | 0.9697 | 1.34 (0.74 to 2.42) | 0.3333 |
*Adjusted by age at baseline, gender, ethnicity, socioeconomic status, years of instruction, medical coverage and first SLICC/ACR damage index (SDI).
†One-point increment in the SDI.
‡Three-point increment in the SDI.
§One-point increment in the damage unrelated to glucocorticoids.
¶Three-point increment in the damage unrelated to glucocorticoids.
**One-point increment in the damage glucocorticoids-related damage.
LDAS, low disease activity status; reference group for HRs: non-optimally controlled.