Table 1

Demographics, year and type of incident ACS, and pre-existing comorbidities and pharmacotherapies among patients with RA and general population comparators with incident ACS between 2007 and 2010

RA
n=1135
Comparators
n=3184
Year of ACS
 2007333 (29.3)802 (25.2)
 2008283 (24.9)832 (26.1)
 2009277 (24.4)808 (25.4)
 2010242 (21.3)742 (23.3)
Type of ACS*
 Transmural MI248 (21.9)648 (20.4)
 Subendocardial MI414 (36.5)1158 (36.4)
 Unspecific MI363 (32.0)906 (28.5)
 Unstable angina103 (9.1)468 (14.7)
 Reinfarction7 (0.6)4 (0.1)
 Women711 (62.6)1897 (59.6)
 Men424 (37.4)1287 (40.4)
Age, median (SD)73.8 (±10.3)73.6 (±9.8)
 Women74.9 (±9.7)75.4 (±10.1)
 Men71.6 (±9.6)71.5 (±10.3)
Educational level (years)
 <9602 (53.0)1739 (54.6)
 10–12390 (34.4)1057 (33.2)
 >12124 (10.9)344 (10.8)
RA treatment 0–6 months prior ACS
 Glucocorticoid687 (60.5)  –
 DMARD, any648 (57.1)  –
 DMARD, Mtx491 (43.3)  –
 Biological drug105 (9.3)  –
 NSAID749 (66.0)  –
Pre-existing CVD†
 Stable angina pectoris197 (17.4)468 (14.7)‡
 Cerebrovascular lesion150 (13.2)388 (12.2)
 Venous thromboembolic disease117 (10.3)211 (6.6)§
 Atrial fibrillation114 (10.0)286 (9.0)
 Congestive heart failure175 (15.4)332 (10.4)§
 Cardiomyopathy10 (0.9)33 (1.0)
Pre-existing other comorbidities†
 Diabetes, type I98 (8.6)283 (8.9)
 Diabetes, type II171 (15.1)504 (15.8)
 COPD124 (10.9)221 (6.9)§
 Renal failure, chronic28 (2.5)53 (1.7)
Pre-existing pharmacotherapy†
 Insulin113 (10.1)320 (10.0)
 Oral antidiabetics108 (9.5)410 (12.9)‡
 Warfarin118 (10.4)241 (7.6)‡
 Acetylsalicylic acid 403 (35.5)1261 (39.6)‡
 P2Y12 inhibitors51 (4.5)98 (3.1)‡
 Nitro238 (21.0)616 (19.4)
 Diuretics545 (48.0)1222 (38.4)§
 ACE inhibitors459 (40.4)1230 (38.6)
 Beta blocker557 (49.1)1395 (43.8)‡
 Calcium antagonists298 (26.3)871 (27.4)
 Lipid reducers280 (24.7)932 (29.3)‡
  • *Based on the ICD diagnoses registered in the Swedish Patient Register (unstable angina ICD I200, transmural MI ICD I210–I213, subendocardial MI ICD I214, unspecific MI ICD I219, reinfarction ICD I22).

  • †All pre-existing comorbidities/dispensed pharmacotherapies are defined as a diagnosis or fulfilled prescription in national patient registry or prescribed drug registry more than 3 months prior to the ACS. ICD codes used in online supplementary file.

  • ‡p<0.05 based on χ2 test for dichotomous variables, t-test for normally distributed continuous variables, and Mann-Whitney U test for ordinal/non-normally distributed continuous variables.

  • §p<0.0001 based on χ2 test for dichotomous variables, t-test for normally distributed continuous variables, and Mann-Whitney U test for ordinal/non-normally distributed continuous variables.

  • ACS, acute coronary syndrome; COPD, chronic obstructive pulmonary disease; CVD, cardiovascular disease; DMARD, disease-modifying antirheumatic drugs; ICD, International Statistical Classification of Diseases; MI, myocardial infarction; Mtx, methotrexate, NSAID, non-steroidal anti-inflammatory drugs; RA, rheumatoid arthritis.