Table 2

Ultrasound of major salivary glands versus classification criteria

AECG
Parotid gland biopsyLabial gland biopsy
Optimal cut-off point15/1615/16
% Absolute agreement82.4% (80/97)79.2% (76/96)
Sensitivity71.1% (32/45)67.3% (33/49)
Specificity92.3% (48/52)91.4% (43/47)
PPV88.9% (32/36)89.2% (33/37)
NPV78.7% (48/61)72.9% (43/59)
ACR
Parotid gland biopsyLabial gland biopsy
Optimal cut-off point1515
% Absolute agreement85.6% (83/97)81.7% (76/93)
Sensitivity77.3% (34/44)69.8% (30/43)
Specificity92.4% (49/53)92.0% (46/50)
PPV89.4% (34/38)88.2% (30/34)
NPV83.1% (49/59)78.0% (46/59)
ACR-EULAR
Parotid gland biopsyLabial gland biopsy
Optimal cut-off point1515
% Absolute agreement79.8% (79/99)75.3% (73/97)
Sensitivity67.3% (35/52)61.8% (34/55)
Specificity93.6% (44/47)92.9% (39/42)
PPV92.1% (35/38)91.9% (34/37)
NPV72.1% (44/61)65.0% (39/60)
  • In the left column parotid gland biopsies are considered an item of the AECG, ACR and ACR-EULAR classification criteria. In the right column labial gland biopsies are considered an item of the AECG, ACR and ACR-EULAR criteria.

  • ACR, American College of Rheumatology; AECG, American European Consensus Group; EULAR, European League Against Rheumatism; NPV, negative predictive value; PPV, positive predictive value.