Table 4

Univariate and multivariable linear regression analyses for wrist scores

Δ Baseline–1-year follow-upΔ Baseline–5 years follow-up
UnivariateMultivariableUnivariateMultivariable
β (95% CI)p Valueβ (95% CI)p Valueβ (95% CI)p Valueβ (95% CI)p Value
HAQ
 ΔRI synovitis0.06 (0.02 to 0.10)0.010.09 (0.03 to 0.15)0.0030.07 (0.01 to 0.13)0.02
 ΔMRI tenosynovitis0.04 (0.02 to 0.07)0.0010.04 (0.00 to 0.07)0.04
 ΔMRI osteitis0.02 (0.00 to 0.03)0.050.02 (0.00 to 0.05)0.10
 ΔMRI erosion0.01 (−0.07 to 0.08)0.85−0.03 (−0.06 to 0.01)0.11
 ΔJSN−0.01 (−0.13;0.11)0.84−0.05 (−0.11 to 0.02)0.16
 ΔSJC0.03 (0.02 to 0.05)<0.000010.02 (0.01 to 0.04)0.010.04 (0.02 to 0.06)0.001
 ΔCRP0.01 (0.01 to 0.01)0.000020.01 (0.01 to 0.01)<0.000010.01 (0.00 to 0.01)0.0010.01 (0.00 to 0.01)0.02
 ΔMRI combined inflammation*0.01 (0.00 to 0.02)0.010.02 (0.01 to 0.04)0.010.02 (0.00 to 0.04)0.02
 ΔMRI combined damage*0.00 (−0.05;0.06)0.93−0.02 (−0.04 to 0.00)0.11
VAS-PtGlobal
 ΔMRI synovitis3.08 (1.18 to 4.98)0.0022.53 (0.65 to 4.41)0.014.56 (2.33 to 6.79)0.00013.37 (0.95 to 5.79)0.01
 ΔMRI tenosynovitis1.11 (0.02 to 2.21)0.051.33 (0.01 to 2.65)0.05
 ΔMRI osteitis0.70 (0.02 to 1.39)0.051.33 (0.43 to 2.23)0.004
 ΔMRI erosion−1.22 (−4.63;2.20)0.50−0.84 (−2.07 to 0.40)0.18
 ΔMRI JSN0.40 (−5.01;5.81)0.89−1.82 (−4.26 to 0.62)0.14
 ΔSJC0.83 (0.13 to 1.53)0.021.94 (1.16 to 2.72)<0.000011.29 (0.31 to 2.27)0.01
 ΔCRP0.28 (0.15 to 0.38)0.000020.22 (0.10 to 0.35)0.0010.22 (0.06 to 0.38)0.01
 ΔMRI combined inflammation*0.50 (0.04 to 0.96)0.031.11 (0.54 to 1.67)0.00020.78 (0.14 to 1.42)0.02
 ΔMRI combined damage*−0.58 (−3.15;2.00)0.66−0.62 (−1.46 to 0.23)0.15
VAS-pain
ΔMRI synovitis3.54 (1.82 to 5.27)0.000082.90 (1.20 to 4.61)0.0015.57 (3.52 to 7.61)<0.000012.53 (0.22 to 4.84)0.03
 ΔMRI tenosynovitis1.18 (0.18 to 2.18)0.021.83 (0.58 to 3.09)0.01
 ΔMRI osteitis0.60 (−0.03;1.23)0.061.49 (0.63 to 2.35)0.001
 ΔMRI erosion−1.94 (−5.03;1.15)0.22−1.12 (−2.31 to 0.07)0.07
 ΔMRI JSN1.92 (−3.32;7.17)0.47−1.51 (−3.89 to 0.87)0.21
 ΔSJC1.01 (0.38 to 1.63)0.0012.20 (1.52 to 2.89)<0.000010.86 (−0.01;1.74)0.05
 ΔCRP0.27 (0.16 to 0.37)<0.000010.22 (0.10 to 0.33)0.00020.40 (0.26 to 0.53)<0.000010.26 (0.10 to 0.41)0.00
 ΔMRI combined inflammation*0.52 (0.10 to 0.94)0.021.33 (0.80 to 1.85)<0.000010.96 (0.37 to 1.56)0.00
 ΔMRI combined damage*−0.71 (−3.06;1.65)0.55−0.71 (−1.53 to 0.10)0.09
  • *If combined inflammation or damage scores in univariate regression analyses had a p value ≤0.10, this was included in a separate multivariable regression model with CRP and SJC.

  • Analyses for associations between the change of MRI features and change in patient-reported outcomes. All multivariable analyses were adjusted for sex and age. Statistically significant or borderline significant p values (≤0.05) are written in bold.

  • Δ, change; CRP, C reactive protein; HAQ, health assessment questionnaire; JSN, joint space narrowing; PtGlobal, patient global; SJC, swollen joint count; VAS, visual analogue scale.