Univariate and multivariable linear regression analyses for wrist scores
| Δ Baseline–1-year follow-up | Δ Baseline–5 years follow-up | |||||||
| Univariate | Multivariable | Univariate | Multivariable | |||||
| β (95% CI) | p Value | β (95% CI) | p Value | β (95% CI) | p Value | β (95% CI) | p Value | |
| HAQ | ||||||||
| ΔRI synovitis | 0.06 (0.02 to 0.10) | 0.01 | 0.09 (0.03 to 0.15) | 0.003 | 0.07 (0.01 to 0.13) | 0.02 | ||
| ΔMRI tenosynovitis | 0.04 (0.02 to 0.07) | 0.001 | 0.04 (0.00 to 0.07) | 0.04 | ||||
| ΔMRI osteitis | 0.02 (0.00 to 0.03) | 0.05 | 0.02 (0.00 to 0.05) | 0.10 | ||||
| ΔMRI erosion | 0.01 (−0.07 to 0.08) | 0.85 | −0.03 (−0.06 to 0.01) | 0.11 | ||||
| ΔJSN | −0.01 (−0.13;0.11) | 0.84 | −0.05 (−0.11 to 0.02) | 0.16 | ||||
| ΔSJC | 0.03 (0.02 to 0.05) | <0.00001 | 0.02 (0.01 to 0.04) | 0.01 | 0.04 (0.02 to 0.06) | 0.001 | ||
| ΔCRP | 0.01 (0.01 to 0.01) | 0.00002 | 0.01 (0.01 to 0.01) | <0.00001 | 0.01 (0.00 to 0.01) | 0.001 | 0.01 (0.00 to 0.01) | 0.02 |
| ΔMRI combined inflammation* | 0.01 (0.00 to 0.02) | 0.01 | 0.02 (0.01 to 0.04) | 0.01 | 0.02 (0.00 to 0.04) | 0.02 | ||
| ΔMRI combined damage* | 0.00 (−0.05;0.06) | 0.93 | −0.02 (−0.04 to 0.00) | 0.11 | ||||
| VAS-PtGlobal | ||||||||
| ΔMRI synovitis | 3.08 (1.18 to 4.98) | 0.002 | 2.53 (0.65 to 4.41) | 0.01 | 4.56 (2.33 to 6.79) | 0.0001 | 3.37 (0.95 to 5.79) | 0.01 |
| ΔMRI tenosynovitis | 1.11 (0.02 to 2.21) | 0.05 | 1.33 (0.01 to 2.65) | 0.05 | ||||
| ΔMRI osteitis | 0.70 (0.02 to 1.39) | 0.05 | 1.33 (0.43 to 2.23) | 0.004 | ||||
| ΔMRI erosion | −1.22 (−4.63;2.20) | 0.50 | −0.84 (−2.07 to 0.40) | 0.18 | ||||
| ΔMRI JSN | 0.40 (−5.01;5.81) | 0.89 | −1.82 (−4.26 to 0.62) | 0.14 | ||||
| ΔSJC | 0.83 (0.13 to 1.53) | 0.02 | 1.94 (1.16 to 2.72) | <0.00001 | 1.29 (0.31 to 2.27) | 0.01 | ||
| ΔCRP | 0.28 (0.15 to 0.38) | 0.00002 | 0.22 (0.10 to 0.35) | 0.001 | 0.22 (0.06 to 0.38) | 0.01 | ||
| ΔMRI combined inflammation* | 0.50 (0.04 to 0.96) | 0.03 | 1.11 (0.54 to 1.67) | 0.0002 | 0.78 (0.14 to 1.42) | 0.02 | ||
| ΔMRI combined damage* | −0.58 (−3.15;2.00) | 0.66 | −0.62 (−1.46 to 0.23) | 0.15 | ||||
| VAS-pain | ||||||||
| ΔMRI synovitis | 3.54 (1.82 to 5.27) | 0.00008 | 2.90 (1.20 to 4.61) | 0.001 | 5.57 (3.52 to 7.61) | <0.00001 | 2.53 (0.22 to 4.84) | 0.03 |
| ΔMRI tenosynovitis | 1.18 (0.18 to 2.18) | 0.02 | 1.83 (0.58 to 3.09) | 0.01 | ||||
| ΔMRI osteitis | 0.60 (−0.03;1.23) | 0.06 | 1.49 (0.63 to 2.35) | 0.001 | ||||
| ΔMRI erosion | −1.94 (−5.03;1.15) | 0.22 | −1.12 (−2.31 to 0.07) | 0.07 | ||||
| ΔMRI JSN | 1.92 (−3.32;7.17) | 0.47 | −1.51 (−3.89 to 0.87) | 0.21 | ||||
| ΔSJC | 1.01 (0.38 to 1.63) | 0.001 | 2.20 (1.52 to 2.89) | <0.00001 | 0.86 (−0.01;1.74) | 0.05 | ||
| ΔCRP | 0.27 (0.16 to 0.37) | <0.00001 | 0.22 (0.10 to 0.33) | 0.0002 | 0.40 (0.26 to 0.53) | <0.00001 | 0.26 (0.10 to 0.41) | 0.00 |
| ΔMRI combined inflammation* | 0.52 (0.10 to 0.94) | 0.02 | 1.33 (0.80 to 1.85) | <0.00001 | 0.96 (0.37 to 1.56) | 0.00 | ||
| ΔMRI combined damage* | −0.71 (−3.06;1.65) | 0.55 | −0.71 (−1.53 to 0.10) | 0.09 | ||||
*If combined inflammation or damage scores in univariate regression analyses had a p value ≤0.10, this was included in a separate multivariable regression model with CRP and SJC.
Analyses for associations between the change of MRI features and change in patient-reported outcomes. All multivariable analyses were adjusted for sex and age. Statistically significant or borderline significant p values (≤0.05) are written in bold.
Δ, change; CRP, C reactive protein; HAQ, health assessment questionnaire; JSN, joint space narrowing; PtGlobal, patient global; SJC, swollen joint count; VAS, visual analogue scale.