Table 2

Cox-proportional hazard regression analysis with time to first CVD event as the primary outcome and time-dependent DAS28 as the primary independent variable, before (panel A) and after (panel B) correction for confounders. Panel C shows results from the Cox-proportional hazards regression with DAS28 <3.2 (yes/no) as a time-dependent covariate after correction for confounders

	Beta	p Value	HR	95% CI for Exp (B)
	Beta	p Value	HR	Lower	Upper
Panel A: Crude model
Time-dependent covariate (DAS28)	0.113	0.119	1.120	0.972	1.290
Age	0.064	<0.001	2.010	1.344	3.005
Gender	0.698	0.001	1.066	1.047	1.085
Panel B: Corrected model
Time-dependent covariate (DAS28)	0.165	0.032	1.179	1.014	1.370
Age	0.062	<0.001	1.064	1.044	1.084
Gender	0.725	0.001	2.065	1.365	3.123
Hypertension baseline	1.036	<0.001	2.818	1.673	4.745
HDL-c	−0.736	0.043	0.466	0.222	0.977
CVD medication*	−0.515	0.026	0.597	0.379	0.940
DAS28 baseline	0.034	0.687	1.035	0.877	1.220
Panel C: Corrected model
Time-dependent covariate (DAS28 <3.2)	−0.431	0.044	0.650	0.427	0.989
Age	0.064	<0.001	1.066	1.046	1.087
Gender	0.736	0.001	2.088	1.372	3.177
Hypertension	0.977	<0.001	2.656	1.547	4.559
HDL-c	−1.113	0.009	0.329	0.142	0.758
LDL-c	0.177	0.097	1.193	0.969	1.470
CVD medication*	−0.541	0.022	0.582	0.366	0.925
CRP	−0.001	0.538	0.999	0.994	1.003

*Anti-hypertensive medication, lipid lowering medication.
CRP, C-reactive protein; DAS28, 28-joint disease activity score; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol.