Table 3

Number of events (N), person-years at risk (PY) and incidence rates (N/1000 PY) of acute coronary syndrome in new-onset rheumatoid arthritis (RA) identified between 1997 and 2014 and in an individually matched general population comparator

Patients with new-onset RAGeneral population comparator subjectsHR (95% CI) 
 NPYIncidence rate     NPYIncidence rate    
Overall7721 03 8357.4 (6.1 to 8.8)    2418466 9305.2 (4.6 to 5.7)    1.41 (1.29 to 1.54) 
Sex
 Women39573 7495.4 (4.0 to 6.7)    1125329 0873.4 (2.9 to 3.9)    1.53 (1.35 to 1.73) 
 Men37730 08512.5 (9.4 to 15.7)    1293137 8429.4 (8.1 to 10.7)    1.30 (1.15 to 1.47) 
Rheumatoid factor
 Positive51369 0127.4 (5.8 to 9.1)    2418466 9305.2 (4.6 to 5.7)    1.64 (1.48 to 1.83) 
 Negative25934 8237.4 (5.2 to 9.7)    2418466 9305.2 (4.6 to 5.7)    1.09 (0.94 to 1.26) 
DAS28 at diagnosis
 ≤3.24595884.7 (2.7 to 6.7)    2418466 9305.2 (4.6 to 5.7)    0.81 (0.58 to 1.14) 
 >3.265285 3607.6 (6.7 to 8.6)    2418466 9305.2 (4.6 to 5.7)    1.45 (1.32 to 1.60) 
Age at diagnosis
 <535838 4541.5 (0.5 to 2.6)    150176 3020.9 (0.5 to 1.2)    1.76 (1.28 to 2.42) 
 5318628 9296.4 (4.0 to 8.9)    483130 8743.7 (2.8 to 4.6)    1.73 (1.45 to 2.07) 
 63≤7222420 87910.7 (7.3 to 14.1)    71892 7967.7 (6.4 to 9.1)    1.37 (1.17 to 1.61) 
 ≥7230415 57119.5 (14.5 to 24.5)    106766 95615.9 (13.8 to 18.1)    1.22 (1.06 to 1.40) 
Calendar period
 1997–200237542 3638.9 (5.7 to 12.0)    1209191 8496.3 (5.0 to 7.6)    1.41 (1.24 to 1.60) 
 2003–200620828 5757.3 (4.3 to 10.2)    603127 1854.7 (3.6 to 5.9)    1.47 (1.24 to 1.74) 
 2007–201014423 4136.2 (3.8 to 8.5)    441105 2644.2 (3.3 to 5.1)    1.38 (1.13 to 1.68) 
 2011–20144594834.7 (2.8 to 6.7)    16542 6303.9 (3.1 to 4.7)    1.19 (0.85 to 1.67) 
  • HR and 95% CI with the matching factors taken into account and adjusted for age and educational level. By sex, serostatus, DAS28 at diagnosis, age at diagnosis and calendar period of diagnosis.

  • DAS28, Disease Activity Score 28.